FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.
The (Sr.) Microbial Engineer will be primarily responsible for the design, testing, and analysis of new delivery modalities. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.
Design and execute experiments to validate the FL62 platform
Develop methods to produce and characterize bacterial products
Work with senior leadership to develop and execute the scientific vision
Collaborate with CROs and other outside entities
Manage and mentor a team of junior scientists and research associates
Oversee molecular biology assay development.
PhD and 2 yrs of postdoctoral or industrial experience in bioengineering, microbiology, or chemical engineering
Experience growing and engineering diverse bacteria including E. coli, Pseudomonas,Xanthomonas, Salmonella, and Serratia
Experience developing auxotrophic versions of the above species
Experience with modern large-scale knockout creation methods, such as CRISPR and lambda red recombineering
Experience working on bacterial energetics or flux analysis
Experience producing bacteria in benchtop and laboratory-scale fermentation reactors
Experience with filtration and purification technologies, such as ultracentrifugation, Tangential Flow Filtration, or irradiation.
Excellent verbal and written communication skills
Strong organizational skills
Ability to work in a fast-paced and quickly changing environment
Experience studying or modulating host-microbe interactions, including virulence, secretion systems, secreted toxins, and surface protein interactions.
Experience with plant, fungal, or mammalian host-microbe interaction research
Experience developing assays for novel synthetic biology applications
Experience with high throughput screening technologies
Experience with synthetic biology gene circuits
If you are interested please reach out to David Kolesky directly: firstname.lastname@example.org.