(Sr.) Microbial Engineer

Company Overview

FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.

Position Summary

The (Sr.) Microbial Engineer will be primarily responsible for the design, testing, and analysis of new delivery modalities. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.

Key Responsibilities:

  • Design and execute experiments to validate the FL62 platform

  • Develop methods to produce and characterize bacterial products

  • Work with senior leadership to develop and execute the scientific vision

  • Collaborate with CROs and other outside entities

  • Manage and mentor a team of junior scientists and research associates

  • Oversee molecular biology assay development.

Required Skills/Experience:

  • PhD and 2 yrs of postdoctoral or industrial experience in bioengineering, microbiology, or chemical engineering

  • Experience growing and engineering diverse bacteria including E. coliPseudomonas,XanthomonasSalmonella, and Serratia

  • Experience developing auxotrophic versions of the above species

  • Experience with modern large-scale knockout creation methods, such as CRISPR and lambda red recombineering

  • Experience working on bacterial energetics or flux analysis

  • Experience producing bacteria in benchtop and laboratory-scale fermentation reactors

  • Experience with filtration and purification technologies, such as ultracentrifugation, Tangential Flow Filtration, or irradiation.

  • Excellent verbal and written communication skills

  • Strong organizational skills

  • Ability to work in a fast-paced and quickly changing environment

Desired Skills/Experience:

  • Experience studying or modulating host-microbe interactions, including virulence, secretion systems, secreted toxins, and surface protein interactions.

  • Experience with plant, fungal, or mammalian host-microbe interaction research

  • Experience developing assays for novel synthetic biology applications

  • Experience with high throughput screening technologies

  • Experience with synthetic biology gene circuits

If you are interested please reach out to David Kolesky directly: dkolesky@flagshippioneering.com.