(Sr.) Microbiologist

Company Overview

FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.

Position Summary

The (Sr.) Microbiologist will be primarily responsible for developing FL62’s biological delivery tools utilizing diverse microbes. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.

Key Responsibilities:

  • Design and execute experiments to validate the FL62 platform

  • Develop methods to repurpose microbe-host interactions

  • Work with senior leadership to develop and execute the scientific vision

  • Collaborate with CROs and other outside entities

  • Manage and mentor a team of junior scientists and RAs

Required Skills/Experience:

  • PhD and 2 yrs of postdoc or industrial experience in bioengineering, microbiology, or chemical engineering

  • Excellent understanding of host-microbe interactions, including secretion systems, secreted molecules, and surface protein interactions.

  • Experience with plant, fungal, or mammalian host-microbe interaction research

  • Experience growing and engineering diverse bacteria including E. coliPseudomonas, XanthomonasSalmonella, and Serratia.

  • Experience developing auxotrophic versions of the above species

  • Experience with inducible gene expression vectors

  • Experience producing bacteria in benchtop and laboratory-scale fermentation reactors

  • Experience with filtration and purification technologies, such as ultracentrifugation, tangential flow filtration, or irradiation.

  • Experience with novel assay development including reporter assays, molecular, and immune assays.

  • Excellent verbal and written communication skills

  • Strong organizational skills

  • Ability to work in a fast-paced and quickly changing environment

Desired Skills/Experience:

  • Experience engineering bacterial surface proteins or secreted effector proteins

  • Experience moving heterologous systems into model bacteria (e.g. E. coli)

  • Experience with extremophiles, cyanobacteria, or magnetotactic bacteria

  • Experience collecting human (e.g. fecal) and/or environmental (e.g. soil) bacterial isolates

  • Experience with studying microbe virulence factors

  • Experience working on bacterial energetics or flux analysis

If you are interested please reach out to David Kolesky directly: dkolesky@flagshippioneering.com.