Company: Regeneron

Position: Scientist/Staff Scientist, Oncolytic Virus Therapy
Location: Tarrytown, NY, US

About Regeneron Pharmaceuticals:

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. 

Summary:
Regeneron is seeking a highly motivated and innovative Scientist to work in development of novel oncolytic virus vectors. The person will lead design, generation, in vitro and in vivo testing of oncolytic vectors, utilize and further enhance existing proprietary technologies.

Duties:
Design, generate, validate and test novel oncolytic virus vectors in mouse tumor models.
Participate in advancement of candidates into clinical development.
Present findings internally and externally.
Collaborate closely with colleagues within Infectious Diseases, Oncology and Angiogenesis, Viral Vector Technologies and across the organization.
Supervise Research Associates, as assigned.

Requirements:
PhD with a solid background in virology (including viral genome analysis and manipulation), cell biology, tumor biology/immunology with interest in oncolytic virus therapy.
Understanding of viral interactions with the immune system.
Previous experience in vectorology, immunotherapy or oncolytic virus-therapy, working with animal models of human cancers and immunological assays are highly desirable.
Demonstrated productivity in collaborative environments.
Highly organized and motivated.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron’s unwavering commitment to combining good science & good business at: https://careers.regeneron.com/job/REGEA0026305030/Scientist-Staff-Scientist-Oncolytic-Virus-Therapy

EEO

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law. 

Company: Suono Bio

Position: Scientist
Location: Cambridge, MA, US

Suono Bio is a preclinical-stage company specializing in the ultra-rapid delivery of novel therapeutics to the gastrointestinal (GI) tract. The company was co-founded by Professor Robert Langer (MIT), Dr. Giovanni Traverso (Harvard Medical School), Amy Schulman (Polaris Partners), and Carl Schoellhammer and is based out of MIT’s The Engine. The company’s platform delivery technology enables the localized administration of therapeutics, including biologics and nucleic acids, in a formulation independent manner. The technology has been published in Science Translational Medicine and Gastroenterology and has won national awards including the Lemelson MIT National Inventors Prize and the National Collegiate Inventors Competition. The company was also awarded a Golden Ticket to LabCentral (Cambridge, MA) from Bristol-Myers Squibb. The company is backed by venture funding from the LS Polaris Innovation Fund and MIT’s The Engine.

We currently seek a highly motivated, driven, and collaborative Scientist with experience in molecular and cellular biology and animal models to contribute to the company’s R&D program. The chosen candidate must possess an outstanding track record that demonstrates a proven ability to drive research progress, including the ability to independently design, implement, and troubleshoot experiments and effectively present results and research plans.

Responsibilities will involve laboratory and operational roles, including:

• Design and carry-out critical experiments
• Cell-based assays, including FACS
• Tissue dissection, staining, and immunohistochemistry
• Cloning, real-time PCR, and sequencing
• Pre-clinical animal studies
• Scientific writing and presentation

Ideal Qualifications:

• Ph.D. from a top-tier school with a proven record of publication
• 2+ years post terminal degree (5-10 years preferred)
• Experience with animal handling and testing
• Well-developed analytical skill set applicable to protein and nucleic acid analysis
• Excellent written and oral communication skills
• Prior interactions with industrial partners preferred
• Capable of working independently in a small, fast-paced environment
• Excitement for breakthrough research and creativity in how technology is applied
• A desire to learn new skills and grow along with us

Candidates should send their resumes to: info@suonobio.com

 

Company: Kaleido Biosciences, Inc

Position: Intern
Location: Bedford, MA, US

Kaleido Biosciences, Inc. has immediate openings for full-time 6 months internships

Kaleido Biosciences is pioneering a novel category of therapeutics, built upon our unique chemistry platform, to systematically modulate the human microbiome for the treatment of disease and the promotion of health. Kaleido was founded by VentureLabs, a unit of Flagship Pioneering which has launched over 25 breakthrough companies including Seres Therapeutics, Indigo, Axcella Health, and Moderna Therapeutics.

During this 6-month internship you will be a valuable member of our energetic and collaborative
research team. Your mission is to help us advance our understanding of the role of the gut
microbiome in human health, and help us develop drugs to manipulate and repair the damaged
microbiome.
• Work on a personal project that is important to Kaleido’s mission.
• Be supported by a mentor who will provide a unique perspective on projects and careers.
• Have the opportunity to participate in the pioneering discoveries of novel chemistries that
control the microbiome.

Qualifications:
• Pursuing a graduate degree in Microbiology, Molecular Biology, Biochemistry, Cell Biology, Chemistry, Computational Biology, and
   related fields.
• Applicants should bring a strong sense of curiosity, rigorous scientific training, a willingness to work as part of an integrated, high energy
   multi-disciplinary team, and a desire to learn the art and science of drug discovery.

Other information:
• Kaleido is accessible via public transportation. Interns are welcome to join our cycling team commuting from Boston and Cambridge.
• Participation is greatly encouraged in weekly events: company “All minds” Wednesday lunch, Research group meeting with lunch
   provided, Biology team research meeting on Mondays, and Thursday’s “chalk talk” aimed to provide a forum for learning about research
   and non-research activities at Kaleido.
• Intern contributing to a project that results in a scientific publication, would be added as a co-author.

Contact Tanya Yatsunenko for more information
tyatsunenko@kaleido.com
www.linkedin.com/in/yatsunenko 

 

Company: Kaleido Biosciences, Inc

Position: Intern
Location: Bedford, MA, US

Kaleido Biosciences, Inc. has immediate openings for full-time 6 months internships

Kaleido Biosciences is pioneering a novel category of therapeutics, built upon our unique chemistry platform, to systematically modulate the human microbiome for the treatment of disease and the promotion of health. Kaleido was founded by VentureLabs, a unit of Flagship Pioneering which has launched over 25 breakthrough companies including Seres Therapeutics, Indigo, Axcella Health, and Moderna Therapeutics.

During this 6-month internship you will be a valuable member of our energetic and collaborative
research team. Your mission is to help us advance our understanding of the role of the gut
microbiome in human health, and help us develop drugs to manipulate and repair the damaged
microbiome.
• Work on a personal project that is important to Kaleido’s mission.
• Be supported by a mentor who will provide a unique perspective on projects and careers.
• Have the opportunity to participate in the pioneering discoveries of novel chemistries that
control the microbiome.

Qualifications:
• Pursuing a graduate degree in Microbiology, Molecular Biology, Biochemistry, Cell Biology, Chemistry, Computational Biology, and
   related fields.
• Applicants should bring a strong sense of curiosity, rigorous scientific training, a willingness to work as part of an integrated, high energy
   multi-disciplinary team, and a desire to learn the art and science of drug discovery.

Other information:
• Kaleido is accessible via public transportation. Interns are welcome to join our cycling team commuting from Boston and Cambridge.
• Participation is greatly encouraged in weekly events: company “All minds” Wednesday lunch, Research group meeting with lunch
   provided, Biology team research meeting on Mondays, and Thursday’s “chalk talk” aimed to provide a forum for learning about research
   and non-research activities at Kaleido.
• Intern contributing to a project that results in a scientific publication, would be added as a co-author.

Contact Tanya Yatsunenko for more information
tyatsunenko@kaleido.com
www.linkedin.com/in/yatsunenko 

 

Company: Organ Preservation Alliance

Position: Grantwriter

Our 501(c)(3) non-profit, the Organ Preservation Alliance (organpreservationalliance.org), is preparing to launch a program to connect researchers in the fields of organ preservation and cryopreservation to grantwriting support. 

We are experimenting with a mix of models (in-house, outsourced to firms, outsourced to freelancers), with the goal of finding the best possible grantwriters to work steadily and intensely on building multiple research centers.

We’ll initially allocate up to $250,000 to this program. If successful, the goal would be to develop long-term partnerships with professional grantwriters that would generate millions fees over the next few years. We’re launching a research center ($1 million committed, aiming to raise $5-10 million total seed funding). The center will rely heavily on professional grantwriting services.

If things go well, we'd be open to giving a full-time job offer. 

If you are interested, please send your résumé and at least one writing sample to alex.mooney@organpreservationalliance.org.

 

Company: Find.Bio

Position: Development and Consulting

Find-dot-Bio-(BW).png

Find.Bio is a venture-backed startup using large-scale simulations, advanced analytics (including machine learning), and lab robotics to identify the biological mechanisms of disease, and molecules to target these.  Our pilot project is focused on liver-stage malaria.

We're looking for someone with experience setting up and running molecular dynamics simulations.  (Experience with QM methods ideal, but not required.)  Part time, mix of development and consulting.

Contact team@find.bio

 

Company: DeepBiome Therapeutics, Inc.

Position: Scientist
Location: Boston, MA, US

At DeepBiome, we have a different vision for drug discovery. Digital. Scalable. Automatable. The future of pharma is nothing like the status quo.

Description:

DeepBiome Therapeutics, a top VC-backed startup company founded by alumni scientists from the Broad Institute of MIT and Harvard, works at the cutting edge of the microbiome, deep learning, and synthetic biology fields. We are building a new drug discovery platform. Join us.

Responsibilities:

Hands on synthetic biologist for various microbial engineering projects.

You will culture, identify, and genetically manipulate newly isolated microbes from the human microbiome using cutting-edge technologies.

Apply expertise in techniques including:

  • PCR with primer/probe design
  • DNA cloning and assembly methods - such as Golden Gate, Gibson assembly, etc.
  • Site directed mutagenesis
  • Transformation and microbial culture
  • Next generation sequencing
  • Excellent communication skills while working within an interdisciplinary team of scientists in an intensive environment.

Qualifications include:

A PhD in bioengineering, molecular biology, microbiology, or a related biological sciences degree or MSc degree with 4+ years of experience in the biotechnology industry.

A meticulous, innovative, and self-motivated scientist with a strong desire to develop a revolutionary drug discovery platform for accelerating identification of novel therapeutic candidates.

Tangibles:

Competitive salary and benefits.

To apply:

Please send resume to apply@deepbiometherapeutics.com

 

Company: Vertex Pharmaceuticals

Position: Intern, Computational Genomics
Location: Boston, MA, US

Vertex Computational Genomics is seeking a talented intern (graduate level) to join our team in Boston, MA.  Computational Genomics intern will contribute to Vertex research projects by analyzing, visualizing, and interpreting high-throughput transcriptomic and/or proteomic datasets to discover new targets or pathways and help understand mechanism of action of Vertex compounds.  Strong background in computational genomic analysis is required.  Strong collaboration and communication skills are essential.
 
Key Responsibilities:

  • Analyze, visualize, and interpret large-scale transcriptomic and/or proteomic data.
  • Present results to project team biologists and collaborate to interpret findings and design potential follow-up experiments.

Minimum Qualifications:

  • Currently pursuing a graduate degree in computational biology, bioinformatics, human genetics, or a related field in the biological data sciences.
  • A proven record in the analysis, visualization, and interpretation of large ‘omics’ data sets. 
  • Solid understanding of statistics and expertise in R or Python.
  • Experienced with high-performance computing environment.
  • Strong communication and presentation skills and ability to work both independently and collaboratively with project teams.

 Preferred Qualifications:

  • Expertise in large-scale RNA-seq or proteomics analysis.
  • In-depth knowledge of genome annotation and pathway biology resources.
 

Company: Navigant Consulting, Inc.

Position: Sr. Consultant, Life Sciences Advisory
Location: Boston, MA, US; New York City, NY, US; Chicago, IL, US; San Francisco, CA, US; Princeton, NJ, US; Philadelphia, PA, US; Minneapolis, MN, US; Los Angeles, CA, US

NAVIGANT (NYSE: NCI) is a specialized, global expert services firm dedicated to assisting clients in creating and protecting
value in the face of critical business risks and opportunities. Navigant professionals combine technical expertise with business
pragmatism in highly‐regulated industries to support clients in addressing their most critical business needs. The Company
has more than 5,000 employees and a geographic presence in over 50 cities globally. Navigant Consulting has been recognized
as one of the Top 50 Energy and Healthcare Consulting Firms by Vault.com; as a Best Place to Work for LGBT Equality by the
Human Rights Campaign (HRC); and one of 2017’s Best Mid‐Sized Employers by Forbes. Navigant is also ranked in the
Modern Healthcare list of Top 20 Healthcare Management Consulting Firms. Visit www.navigant.com/careers.  

Navigant Life Sciences is the Life Science strategic consulting arm of the Navigant’s Healthcare Practice. Our
clients include companies in the pharmaceutical, biotechnology, medical device, drug delivery and diagnostic
industries. Examples of Navigant Life Science’s diverse consulting assignments include therapeutic area strategy
development, product opportunity assessments, commercial strategy, business development search and
evaluations, due diligence, market access strategy, new product launch planning and positioning, and payer
landscape assessments.  Our clients are worldwide and range in size from start‐ups to multi‐nationals.   Navigant
Life Science’s culture is distinguished by its collegial, team approach.  We value hard work of the highest quality
and also encourage creativity, entrepreneurship, and having fun.

   
Responsibilities:

Senior Consultants contribute to all levels of the consulting process and are responsible for the day‐to‐day
management of consulting assignments including regular interactions with clients.  Specific responsibilities
include: analyzing scientific, clinical, financial and strategic information to discerning the business implications of
new technologies and emerging trends; conducting primary research interviews with clinicians, thought leaders,
and executives in the healthcare industry and related fields; managing and mentoring junior staff; and preparing
and presenting written reports to Navigant senior management and clients.  Travel is project dependent but
averages 15 to 20 percent.


Qualifications:

  • Graduating with a MBA, MD or a PhD in a science‐related field by June 2018
  • Prior work experience in the healthcare industry or consulting preferred
  • Demonstrated interest in Life Sciences consulting
  • Exhibit critical thinking, creativity, and strong oral and written communication skills
  • Must exhibit ability to grasp clinical and business implications of technically complex products and services
  • Must exhibit project management skills and ability to manage multiple work streams
  • Ability to supervise and coach team members
  • Must demonstrate willingness to travel and work overtime when required

Benefits
We offer a competitive compensation package that includes an annual incentive compensation plan, a
comprehensive health insurance program, a matching 401(k) program, and employee stock purchase plan.   


Navigant is an Equal Opportunity / Affirmative Action employer. All qualified applicants will receive
consideration for employment without regard to race, color, national origin, ancestry, citizenship status, protected
veteran status, religion, creed, physical or mental disability, medical condition, marital status, sex, sexual
orientation, gender identity or expression, age, or any other basis protected by law, ordinance, or regulations.

 

Company: Navigant Consulting, Inc.

Position: Consultant, Life Sciences Advisory
Location: Boston, MA, US; New York City, NY, US; Chicago, IL, US; San Francisco, CA, US; Princeton, NJ, US; Philadelphia, PA, US; Minneapolis, MN, US; Los Angeles, CA, US

NAVIGANT (NYSE: NCI) is a specialized, global expert services firm dedicated to assisting clients in creating and protecting
value in the face of critical business risks and opportunities. Navigant professionals combine technical expertise with business
pragmatism in highly‐regulated industries to support clients in addressing their most critical business needs. The Company
has more than 5,000 employees and a geographic presence in over 50 cities globally. Navigant Consulting has been recognized
as one of the Top 50 Energy and Healthcare Consulting Firms by Vault.com; as a Best Place to Work for LGBT Equality by the
Human Rights Campaign (HRC); and one of 2017’s Best Mid‐Sized Employers by Forbes. Navigant is also ranked in the
Modern Healthcare list of Top 20 Healthcare Management Consulting Firms. Visit www.navigant.com/careers.  

Navigant Life Sciences is the Life Science strategic consulting arm of the Navigant’s Healthcare Practice. Our clients include
companies in the pharmaceutical, biotechnology, medical device, drug delivery and diagnostic industries. Examples of
Navigant Life Science’s diverse consulting assignments include therapeutic area strategy development, product opportunity
assessments, commercial strategy, business development search and evaluations, due diligence, market access strategy, new
product launch planning and positioning, and payer landscape assessments.  Our clients are worldwide and range in size
from start‐ups to multi‐nationals.   Navigant Life Science’s culture is distinguished by its collegial, team approach.  We value
hard work of the highest quality and also encourage creativity, entrepreneurship, and having fun.   


Responsibilities:
This is a highly challenging position that draws heavily upon all of the analytical, creative, and interpersonal skills essential to
effective general strategy consulting.  Consultants work with Navigant Life Science teams providing support through all
aspects of project work.  Specific tasks include the following:   scheduling and conducting interviews with physicians, payers,
and other thought leaders in healthcare; gathering and analyzing medical literature, healthcare market reports and databases;
and participating in document writing, production, and client presentations.  Navigant encourages career development and
hiring for the long term.  Consultants follow a clearly defined career path and continue to deepen their knowledge in the field
of healthcare and the practice of consulting.   Travel is project dependent but averages 15 to 20 percent.   
Qualifications:

  • Graduating with BA/BS or MS degree between December 2017 and June 2018 and majoring in business, science, biomedical engineering, or healthcare policy and planning is preferred
  • Demonstrated interest in Life Sciences consulting
  • Exhibit critical thinking, creativity, and strong oral and written communication skills
  • Demonstrate superior data collection, organizational and analytical skills and a high level of motivation and initiative
  • Must exhibit ability to grasp clinical and business implications of technically complex products and services
  • Must demonstrate willingness to travel and work overtime when required

Benefits
We offer a competitive compensation package that includes an annual incentive compensation plan, a comprehensive health
insurance program, a matching 401(k) program, and employee stock purchase plan.   


The Navigant is an Equal Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for
employment without regard to race, color, national origin, ancestry, citizenship status, protected veteran status, religion,
creed, physical or mental disability, medical condition, marital status, sex, sexual orientation, gender identity or expression,
age, or any other basis protected by law, ordinance, or regulations.

 

Company: Finnegan

Position: Technical Specialist
Location: Boston, MA, US; Washington, D.C., US

Open Positions:

Our Boston and Washington, DC offices are seeking Technical Specialists with an advanced degree in biology or a related discipline.

Responsibilities of Technical Specialists:

Responsibilities of Technical Specialists include:

  • Preparing patent applications for filing with the US Patent and Trademark Office; 
  • Evaluating the underlying technology of inventions;
  • Opinion writing;
  • Client counseling;
  • Litigation support;
  • Providing technical assistance on projects.

For more information about Finnegan’s Technical Specialist program, follow this link: https://www.finnegan.com/en/careers/roles/technical-specialists.html.

Required Application Materials:

If you are interested in becoming a Technical Specialist with Finnegan, please forward your cover letter, resume, writing sample, and transcripts (undergraduate and graduate).

How to Apply:

For positions in our Boston office:

Christine Brennan, Recruiter

attyrecruit-BOS@finnegan.com

For positions in our Washington, DC office:

Laurie Taylor, Recruiter

attyrecruit-DC@finnegan.com

Company: Biogen

Position: Industrial Postdoc

Job Description

Biogen is a world leader in developing novel treatments for a multitude of neurodegenerative disorders. The preclinical imaging group is offering a 3-4 year postdoctoral position to do neurobiology research within a company setting.

One of the hallmarks of neurological diseases is the disruption of neuronal circuits through either neurodegeneration or changes in the neurons’ electrophysiological properties. An emerging technique to image these circuits is optogenetic fMRI (ofMRI). The preclinical imaging group is embedded in the Research and Early Development biomarker organization of Biogen and offers in-house capabilities spanning MRI, PET, SPECT, CT, bioluminescence, and autoradiography. We are looking for a highly-skilled and motivated candidate to build upon the group’s current optogenetic and fMRI capabilities to help establish an ofMRI platform for the analysis of rodent animal models of neurological disease, including Alzheimer’s Disease, Parkinson’s Disease, and neuropathic pain.

The successful candidate should have previous experience with in vivo optogenetics and the use of genetic animal models. Experience in fMRI or other imaging modality is preferred, although not a prerequisite. The candidate should have a strong interest in method development and creative problem solving, and applying novel methods to study neuronal circuitry in disease models. The candidate will be exposed to the detailed cross functional aspects of drug discovery and development. For this position, the candidate must work closely with other imaging team members, as well as other program teams, and thus strong communication skills and the ability to collaborate are absolutely required and will be demonstrated by presenting at team meetings, internal forums and company-wide seminars. During the post-doctoral term, the candidate will be expected to submit research to both scientific meetings and journals.

Qualifications/Competencies

  • Strong experience with rodent animal models and mouse genetics, including experience with optogenetics
  • Previous experience in imaging is preferred; however, the ability to think mathematically and a strong desire to learn fMRI are essential
  • Strong background in synaptic circuitry in the context of Alzheimer’s Disease, Parkinson’s Disease, and/or pain preferred
  • Team player and effective communicator
  • Strong publication record at conferences and/or peer reviewed journals

Education

  • Recent PhD in neuroscience or related discipline

If interested, please apply through

https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&noback=0&partnerid=169&siteid=5140&jobid=794711#jobDetails=794711_5140

Company: SHEPHERD Therapeutics

Position: Senior Scientist
Location: Natick, MA, US

Company Overview:

SHEPHERD’s mission is to cure rare cancers. Our dedicated team works closely with disease foundations to identify and pursue the highest potential translational science. Our platform-agnostic approach allows us to select the most technologically innovative solutions for patients and to diversify our portfolio of lead compounds across rare cancers, therapeutic platforms, and partnership and licensing structures. Our vision is to change the timeline and economics of drug development for rare cancers. Housed out of the Accelerator and Bio-Incubator ABI-LAB in Natick, MA, SHEPHERD is surrounded and inspired by other life science startup companies. To learn more, visit shepherd.bio.

Position: Senior Scientist

SHEPHERD is seeking a highly motivated, innovative and resourceful Senior Scientist to help advance our understanding of rare cancers and develop novel therapies to treat these indications. The successful candidate will be expected to contribute ideas for new drug discovery projects and develop cellular and molecular assays to investigate the biological activity and therapeutic potential of drug candidates.

  • Time Commitment: Full-time
  • Location: Natick, MA

Key Responsibilities:

  • Design, plan, and execute cell-based and biochemical in vitroexperiments necessary to validate targets for therapeutic discovery.
  • Maintain cell lines and isolate primary cells for use in cell-based assays.
  • Perform in vitro techniques such as tissue culture, gene-knock-down, fluorescence imaging, qPCR, and western blotting to characterize and validate lead drug candidates.
  • Work with the team to design and execute research plans to ensure that critical project requirements, timelines, and deliverables are met.
  • Share and present scientific results to group members and research teams, and at external conferences

Qualifications:

  • PhD degree in oncology, cell biology, molecular biology or related field with 2-5 years of relevant experience.
  • Knowledge/background in oncology and cell signaling pathways.
  • Experience in cell-based assay development is required with emphasis on functional genomic methods for target validation (e.g. siRNA, CRISPR).
  • Significant experience in cell culture techniques including use of mammalian cell lines and primary human cells.
  • Demonstrated ability to work independently and within a team environment including the capability to learn quickly and ability to multi-task
  • Strong research design and analytical skills, with demonstrated ability to problem solve.
  • Excellent communication skills.
 

Company: Regeneron 

Position: Senior Director, Data Management
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

The Sr. Director of Data Management serves as the Clinical Data Management Project Manager to assure CRO’s and vendors are performing in compliance with Regeneron procedures and Regulatory guidance. Additionally, s/he participates on internal project teams to facilitate Data Management communications and coordination. This person works with Vice President to set department goals and objectives, staffing levels and structure, and also directs data management projects to ensure timely completion within project budget guidelines while adhering to all applicable policies and procedures.

Responsibilities include, but not limited to:

  • Determines in conjunction with department Vice President, department goals, appropriate organizational structure and resource allocation for data management to meet company’s needs.
  • Serves as Clinical Data Mgmt Project Manager by providing leadership and management of data management activities. Directs data management activities according to quality standards, regulatory requirements and ensures adherence to project budget from study start up through archival in support of key development programs.
  • Directs and ensures all applicable data management databases are developed, validated, and meeting Regeneron's business requirements. Ensures DM group follows policies and procedures, SOP’s and work instructions in compliance with applicable regulations.
  • Works in collaboration with Quality Assurance and other functional groups to develop and update data management standard processes and procedures in accordance with CFR, GCP, ICH Guidelines and GCDMP minimum standards and best practices. Maintains currency, including regulatory expectations.
  • Contributes to definition and setting of strategy and vision for clinical systems and data standards. Provides business process and technical direction to facilitate adoption and use of technologies for Data Management and trial management.
  • Contributes to development of the Data Management groups strategic alignment with company product profile and clinical development. Provides sourcing strategies and manages long-term relationships with sourcing partners with the objective of ensuring data quality and efficiencies through data and process standardization.
  • Evaluates Data Management partners to ensure efficiency and regulatory compliance. Provides study teams with recommendations on selecting Data Management partners during selection process.
  • Performs all duties expected of a manager, including but not limited to, recruitment, hiring, performance evaluation, training and the like. Establishes goals and accountabilities for staff and sets annual individual and department goals and objectives.
  • Advises all relevant employees about the procedures surrounding retention of data, records, and information for employees in their group.
  • Participates in Regeneron task forces and cross-functional “operational excellence” initiatives.

Requirements:

  • This position requires a minimum of a Bachelor degree in Mathematics, Science or a related field, plus 13 or more years of clinical data management experience in biotechnology, pharmaceutical or health related industry required. At least 9 years in direct managing data management group is required. Additional requirements include:
  • Works independently - self-directed, high energy and strong work ethic. High degree of creativity, latitude and attention to detail required.
  • Up-to-date knowledge on data management process and functions. Knowledge of all applicable regulations including; CFR, GCP, and ICH Guidelines. Strong communication, leadership and DM support of strategic planning and business development skills required.
  • Proficient with the application of EDC, IVR, ePRO, and other remote data capture systems in the industry. Experience with managing projects across various therapeutic areas is required.
  • Report to VP of BDM. Requires the ability to influence others to achieve results. May manage Director, Associate Director and/or managers.

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #9953BR or follow this direct link: https://careers.regeneron.com/job/REGEA0026304003/Senior-Director-Data-Management

 

Company: Regeneron 

Position: Scientist, Bispecific Antibodies
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
We are seeking a highly motivated and innovative PhD scientist to join the Bispecific Antibodies Group. The successful candidate will be responsible for research efforts focused on development of novel antibody-based molecules across multiple therapeutic areas, with a focus on immuno-oncology. The candidate will also support overall team efforts in pre-clinical development of bispecific antibodies. The qualified candidate should have a strong background in antibody/protein engineering, immunology, and/or immuno-oncology.


Duties:
• Design and construct novel bispecific antibodies and related molecules. Express and characterize these molecules in vitro using biochemical and cell-based assays. Develop cell-based functional assays using engineered cell lines and primary cells.
• Conduct proof of concept studies using preclinical tumor models to validate bispecific antibodies and related molecules in vivo.
• Troubleshoot experiments with minimal guidance. Independently analyze data and provide accurate summary to management.
• Present data at group and inter-departmental meetings.
• Maintain complete, accurate, and timely record of experiments and data analysis.
• Develop in depth scientific knowledge in area of research focus and generate new ideas and contribute to decisions on project direction.
• Collaboration with diverse functional groups within the company

Requirements:
• A PhD in Immunology, Oncology, Molecular Biology, or a related field with 3-5 years post-doctoral or industry experience in the relevant fields. 
• Significant experience in antibody/protein engineering and/or immuno-oncology.
• Experiences in cell-based assay development, multi-color FACS analysis, and murine tumor models.
• Excellent communication skills, ability to work productively in a fast-paced collaborative team environment.
• Attention to detail, critical thinking, and an aptitude for learning are also key elements of the position.

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #10998 or follow this direct link: https://careers.regeneron.com/job/REGEA0026304549/Scientist-Bispecific-Antibodies

 

Company: Regeneron 

Position: Scientist/ Staff Scientist, Immuno-Oncology
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

The successful candidate will work on a team that evaluates T cell responses to immune oncology drug therapies. The candidate will be responsible for developing and executing functional assays using clinical materials. This includes both direct ex vivo analysis as well as in vitro immune cell culture. The candidate should be experienced with culturing primary T cells, dendritic cells, and magnetic cell selection.
The position also requires significant experience in multi-color (15+) flow cytometry and cell sorting for downstream analysis.

Responsibilities:
• Collaborate with internal research and clinical teams to develop human T cell functional assays.
• Independently design multicolor flow cytometry panels and perform analysis.
• Independently perform primary cell sorting. Prior experience with single cell sorting preferred.


Requirements:

• Minimum of 5 years of experience in T cell immunology
• Ph.D in immunology or related discipline. Experience in oncology preferred.
Minimum of 5 years of experience with hands-on technical experience in tissue culture, with preference for primary cell culture experience
• Demonstrated mastery of multicolor flow cytometry for T cell characterization
• Strong written and oral communication skills
• Experience working in cross-functional teams

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #10786 or follow this direct link: https://careers.regeneron.com/job/REGEA0026304411/Scientist-Staff-Scientist-Immuno-Oncology

 

Company: Regeneron 

Position: Scientist / Staff Scientist, Immuno-Oncology
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

In this role, the candidate will have an opportunity to perform studies to support bispecific cancer therapeutics in the clinic as well as developing novel agents for hematological cancers. This data generated by the scientist in this position will have an impact on clinical and development decisions. 

Summary:

This position will be responsible for conducting complex in vivo and ex vivo tumor studies in mice using bispecific antibodies as part of the immune-oncology efforts within the Oncology group. This scientist will be responsible for developing new animal models, analyzing data and helping to integrate in vivo information with the goal of advancing leads clinically.
The qualified individual will have a strong background in one or more areas of tumor biology, immunology, oncology and/or immune-oncology with in vivo experience. Expertise in Hematology is a plus.
 Excellent communication and interpersonal skills are also required as this candidate will be expected to work productively in a collaborative, cross-functional team environment.
Attention to detail and timelines coupled with an aptitude for learning are also key elements of the position.

Responsibilities:

• Design, plan and independently perform individual experiments in vivo anti-tumor efficacy studies in mice which requires: cell culture, animal handling including dosing (IV, SC, IP) and measuring tumors as well as dissection.
• Design FACS panels and perform FACS analysis on human cells and murine cells – to investigate immune cell subsets from various organs and tumors
• Understand, analyze, and interpret various forms of data including FACs data and in vivo
efficacy data
• Synthesize results across experiments and programs in PowerPoint presentations
• Present results to more senior scientists and management including clinical and regulatory
teams.
• The candidate must perform meticulous record keeping and generate scientific reports to support preclinical cancer drug development.
• Ability to write documents to support IND filings, patent applications, external conference
posters and journal articles.
Experimental lab work (in the vivarium and well as the laboratory) will be ~ 60-70% of the job
 

Requirements:

• Knowledge of how to design complex studies to interrogate efficacy of novel therapeutic immune-oncology antibodies in vivo.
• Ability to independently perform in vivo efficacy studies in both immunocompetent and immunocompromised mice ( bleeding, tumor implantation and monitoring tumor growth by caliper, IVIS and survival)
• Ability to perform cell culture on human and mouse cells, and to prepare cells to implant tumors into mice.
• Ability to dissect immune organs and tumors from mice and perform ex-vivo immune cell subset analysis by FACS.
• Skilled in development and design of FACS antibody panels to understand mechanism of bispecific antibody therapy in vivo
• Knowledge of FACS analysis and interpretation
• Ability to prepare PowerPoint presentations and present to varied audiences
• Ability to communicate clearly and easily both within the team and across cross-functional teams, both written and verbally
• Ability to write documents to support IND filings, patent applications and external conference posters and journal articles
• 3-5 years following post-doc
This position will require the individual to pass a physical before beginning employment.

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #9951BR or follow this direct link: https://careers.regeneron.com/job/REGEA0026303798/Scientist-Staff-Scientist-Immuno-Oncology

 

Company: Regeneron 

Position: Scientist, Oncology (Imaging/Histology)
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

Seeking a highly motivated individual to join the Oncology team and contribute to the development of novel therapeutics in the field of immuno-oncology. The successful candidate will be responsible for applying histologic techniques and image analysis to better understand the tumor microenvironment and inform our clinical programs. Identification of potential biomarkers and supporting companion diagnostic assays for novel therapeutic targets and agents are included in the scope of this position.

Responsibilities:

• Apply expertise in Immunology, Cancer Biology and/or the Tumor Microenvironment to support pre-clinical and clinical projects
• Provide analysis of histology, immunohistochemistry, RNA in situ hybridization experiments and other tissue-based assays to our immuno-oncology programs from discovery to clinical stage
• Perform image analysis, data management and data QC to inform our clinical PD1 and Lag3 antibody programs
• Work with pathology, precision medicine and research teams to identify and validate biomarkers, using immunohistochemistry, RNA in situ hybridization and other techniques
• Collaborate with Image analysis group, Pathology, Sample Management and Precision Medicine groups to develop image analysis algorithms across different tissue staining platforms
• Identify novel cancer targets using various resources, including scientific literature, patents, bioinformatics databases, knowledge based tools and input from consultants and clinicians
• Explore multiplex imaging modalities with the potential to apply to clinical sample analyses


Requirements:

• PhD or DVM in immunology, oncology, pathology or related fields, with post-doctoral research and/or a minimum of 2 years of experience in industry setting related to translational research
• Strong understanding of Immunology, T cell biology, tumor microenvironment, Immunotherapy for cancer
• Expertise in digital pathology and image analysis platforms such as Indica Halo, Definiens, Tissue Studio, Aperio Image scope, ImageJ, Fiji
• Strong knowledge of tissue-based assays, including immunohistochemistry, in situ hybridization, multiplex imaging modalities, confocal microscopy, live cell-imaging, primary cell culture, flow cytometry, protein detection assays, protein-protein interactions assays.
• Ability to utilize bioinformatics tools effectively
• Ability to design, effectively communicate and implement research plans
• Strong organizational and time management skills
• Abilities to work in a fast-paced multi-functional environment
• Excellent written and verbal communication skills
• Ability to work within a team, coordinating with other Scientists and Research Associates
• Self-motivated, and enthusiastic about curing cancer
 

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #10425BR or follow this direct link: https://careers.regeneron.com/job/REGEA0026304170/Scientist-Oncology-Imaging-Histology

 

Company: Regeneron

Position: Scientist, Immunology & Inflammation
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

Scientist position in the Immunology and Inflammation department with a focus on Immune Modulation mechanisms in the context of autoimmunity. We are seeking a highly motivated, open minded, passionate Scientist with a strong background in the field of immunology with a focus on tissue derived signals and their contribution to local immune cell interactions & immune responses. Deep understanding of stromal cell biology, their interactions with immune cells (e.g. T Cells, pDC, DC, etc.) and contribution to diverse immune mediated pathological conditions is highly desired. Demonstrated ability to translate such knowledge from animal models and/or in vitro primary cell assays and apply it towards the identification of targets/pathways as potential therapeutic modalities for immune diseases. Solid hands-on experience with diverse autoimmune disease models, multicolor flow cytometry, co-culture assay systems; experience with data mining of profiling/sequencing data is highly desired. PhD in immunology with 3-4 years of Postdoctoral studies or minimum 3 years of industry experience. Ability to independently design, execute experiments, propose new targets, handle (maintain lab notebook) and communicate data in a timely manner is required; experience in driving projects is preferred.

Responsibilities:

·        Must have experience in tissue culture. Cell line and primary cell based assay (mouse and human) experience along with knowledge of flow cytometry (multi-color) is a plus.

·       Must have experience conducting experiments using mouse models of autoimmune and inflammatory diseases with training in the proper handling and care of mice, general surgical techniques, and the collection/processing of blood and tissue samples.

·        Must have experience with RNA/DNA isolation and basic molecular biology skills.

·        Must have experience with ELISAs & MSDs, Luminex etc. Histology/RNAScope experience desired.

·        Preferred experience analyzing biological data using GraphPad Prism, FACS DIVA software, FlowJo, SoftMax Pro, and Meso Scale Discovery (MSD) Discovery Workbench software.

·        Preferred experience with primary human cell isolation and design/execution of immunological assays. RNASeq and/or Single cell seq desired.

·        Experience in interpreting, analyzing and presenting research data and working in fast-paced, result oriented research environment and inter-departmental collaborations. Identification of new targets based on data analysis - published or based on own work.

*Contribute to lab and equipment maintenance and order supplies/reagents to help create a safe, effective and efficient working environment.


Requirements:

·        PhD in Immunology Required- 4-5 years of Postdoctoral studies or minimum 3-4 years of industry experience

·       Experience in the field of immunology with a focus on stromal cells/tissue resident cells and their interactions with innate and adaptive immune cells in homeostasis and disease.

·       Solid hands-on experience with multiple autoimmune disease models, multicolor flow cytometry, strong immunology and molecular biology. Ability to creatively apply established knowledge to develop new model systems that capture pathomechanisms from human disease.

·       Strong expertise in independently designing, executing and interpreting autoimmune models, experience with in vitro co-culture assays and patient derived samples is highly preferred. Experience with RNASeq profiling and data mining is highly desired.

·       Strong publication records in related fields in high impact journals, proven record of innovative thinking, strong interpersonal skills, demonstrated ability to collaborate across departments, ability to analyze and effectively present data is a prerequisite.

·       Ability to work in team environment, accountable and collaborative

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #10593BR or follow this direct link: https://careers.regeneron.com/job/REGEA0026304256/Scientist-Immunology-Inflammation

Company: Regeneron 

Position: Research Associate IV-V , Bispecifics (Immuno-Oncology)
Location: Tarrytown, NY, US

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

The Bispecific Antibody team is seeking a highly motivated Senior Research Associate to work on the development and characterization of novel therapeutic antibody molecules and cell therapies focused towards the treatment of cancer and other therapeutic areas. These efforts will determine and validate mechanisms of action for bispecific antibodies and cell therapies both in vitro & in vivo. Successful candidates will be highly motivated and responsible for a broad range of immunological and molecular assays, and be able to support in vivo disease modeling efforts. Specific experience in the development of cell therapies and tumor modeling is highly desirable. 

Responsibilities:

The successful candidate will work to establish/optimize cell-based immunoassays using human PBMC and murine cells to support the preclinical and clinical development of novel bispecific antibodies and cellular therapies. The individual will work in various stages of biologics development, from cloning and expression, validation in vitro and testing mechanisms of action in vivo. A key responsibility will be the support of in vivo disease modeling efforts. Any candidate will be able to integrate into a creative and collegial team environment and must be able to perform experiments with little oversight, analyze and interpret their data, and summarize findings for presentation to colleagues. Suitable candidates will possess strong analytical and organizational skills, be detail orientated, and capable of working on several projects at the same time.

Requirements:

Minimum 5 years of R&D experience in either industry or academic setting after obtaining his / her M.S. degree, or 8 years experience after a Bachelor’s degree.

Technical Skill

Requirements:

·        Comprehensive knowledge of cellular and molecular immunology (innate and adaptive) with a focus on how to enhance and curtail immune cell activation.

·        Experience in expanding T cells – from small to large scale processes.

·        Detailed knowledge of multiparameter flow based assays: quantitation of cell numbers, panel design and optimization, and staining of both cell surface and intracellular antigens. Skilled in data acquisition and analysis, and competency using FlowJo. 

·        Extensive knowledge of preclinical tumor modeling. Must be comfortable in animal handling, tissue collection, and methods of compound administration.

·        Isolation and characterization of hPBMC and murine cells. Enrichment of specific immune cell lineages.
Perform a variety of cellular and analytical based immune assays: cell proliferation and cell death, cytotoxicity assays, measurement of growth factors (MSD, ELISA), ELISpot, MLR, etc.

·        Experience in protein expression with a focus on antibody expression. Knowledge in the generation of ADC’s would be considered favorably.

·        Experience using general biochemical, cellular, and molecular assays: qPCR, general cloning, transduction of immune cells, protein expression, immunoblotting, and gene knockdown technologies is advantageous

·        Data analysis using Prism, Excel.

CORE COMPETENCIES:
 

·        Strong organizational and time-management skills including the ability to handle multiple tasks simultaneously

·        Ability to effectively collaborate as part of cross-functional teams

·        Clearly communicate results

·        Proficient in Microsoft Office.

APPLICATION INSTRUCTIONS: Apply to careers.regeneron.com and search the req #10172BR or follow this direct link: https://careers.regeneron.com/job/REGEA0026304022/Research-Associate-IV-V-Bispecifics-Immuno-Oncology

 

Company: VL49, Inc. 

Position: Scientist-Molecular Biologist
Location: Cambridge, MA, US

 

About VL49, Inc. 

VL49 Inc. is a privately held, well-funded, early-stage biotechnology company that is pioneering a novel transformative therapeutic approach.

VL49 was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics, Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (NASDAQ:SYRS), Rubius Therapeutics, Axcella Health, Evelo Biosciences, Kaleido Biosciences, and Indigo Agriculture. VL49 Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our development team.

Position Summary:

VL49 is seeking a scientist to join our expanding team as a part of our development group. The position requires broad technical experience in molecular biology, with a strong emphasis on critical thinking, multitasking, and the ability to learn new techniques. The successful candidate will help lead and support multidisciplinary project teams focused on the engineering and development of new therapeutic modalities, including nucleic acids, peptides, proteins, cells, and various conjugate molecules. The candidate will focus on all aspects of development spanning conceptualization, experimentation, data analysis, presentation, and strategic planning.

Key Responsibilities

• Strong experimental skills, including mammalian cell culture, viral vector design, and assay development

• Quantitative analysis of biological molecules, including qPCR, DNA/RNA sequencing, flow cytometry, and biochemical assays

• Knowledge of nanotechnology and microfluidic systems

• Execution focused, team oriented, and highly motivated, with strong work ethic

• Contributing to development of the experimental plans to demonstrate the efficacy of therapeutic product candidates

• Manage and oversee CROs, providing technical expertise and direction on production and characterization activities

• Reporting results to scientific team and executive management

• Generate and support intellectual property generation for core projects

• Mentor and train research associates as needed

Minimum Qualifications

• PhD or equivalent in molecular biology, biochemistry, bioengineering, or related disciplines

• Experience with RT-qPCR, RNA-seq, cloning, cell culture, IHC, ELISA, ChIP, EMSA, FISH, Northern, and Western blotting is highly preferred

• Demonstrated ability in working with multidisciplinary teams in a fast-paced, entrepreneurial and technical environment

• Strong scientific understanding of molecular biology and genomics

• Motivated and curious, experienced working with multidisciplinary teams

• Highly adaptable and responsive to technical and business opportunities - comfortable delivering against challenging commitments

• Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment

Application instructions:

Apply to Flagship Pioneering

Company: VL49, Inc. 

Position: Scientist-Computational Biologist
Location: Cambridge, MA, US

 

About VL49, Inc. 

VL49 Inc. is a privately held, well-funded, early-stage biotechnology company that is pioneering a novel transformative therapeutic approach.

VL49 was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics, Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (NASDAQ:SYRS), Rubius Therapeutics, Axcella Health, Evelo Biosciences, Kaleido Biosciences, and Indigo Agriculture. VL49 Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our development team.

Position Summary:

VL49 is seeking a computational biologist to join our expanding team as a part of our development group. The position requires broad technical experience in computational biology, emphasizing the development of novel methods for interrogating high content ‘omics data and improvement of existing approaches. This individual will contribute scientific, technical, and leadership expertise to a multidisciplinary team, emphasizing conceptualization, experimentation, data analysis, presentation, and strategic planning.

Key Responsibilities

• Contribute to the development of new methods and algorithms to glean new biological insights from high throughput ‘omics data

• Process, analyze, interpret, and visualize high volumes of data for the development and validation of approaches

• Written and oral presentation of results to team

• Generate and support intellectual property generation for core projects

• Mentor and train research associates as needed

• Monitor and evaluate analytical aspects of new and emerging technologies

Minimum Qualifications

• PhD in computational biology, (bio)statistics, computer science, or a similar field

• Demonstrated experience with large-scale ‘omics and high throughput data analysis, network analysis, and meta analyses

• Skilled in programming and scripting languages (Python, R, C++, Java)

• Familiar with public domain data sources

• Experience in algorithm generation and/or computational method implementation

• Strong scientific understanding of molecular biology and genomics

• Motivated, curious, execution focused, team oriented, with an ability to thrive in an entrepreneurial and multidisciplinary environment

Application instructions:

Apply to Flagship Pioneering

 

Company: VL50, Inc. 

Position: Scientist-RNA Biologist
Location: Cambridge, MA, US

 

About VL50, Inc.

VL50 Inc. is a privately held, well-funded, early-stage biotechnology company that is pioneering a novel transformative therapeutic approach.

VL50 was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics, Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (NASDAQ:SYRS), Rubius Therapeutics, Axcella Health, Evelo Biosciences, Kaleido Biosciences, and Indigo Agriculture. VL50 Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our development team.

Position Summary:

VL50 is seeking a scientist with a strong background in nucleic acid manipulation and delivery strategies to join our expanding team as a part of our development group. The position requires broad technical experience that spans molecular biology, synthetic biology, and biophysics, with a strong emphasis on critical thinking, multitasking, and the ability to learn new techniques. The successful candidate will help lead and support multidisciplinary project teams focused on the engineering and development of new therapeutic modalities, including nucleic acids, peptides, proteins, cells, and various conjugate molecules. The candidate will focus on all aspects of development spanning conceptualization, experimentation, data analysis, presentation, and strategic planning.

Key Responsibilities

• Design, synthesis, and characterization of novel genetic and biological constructs, sensors, and circuits

• Nucleic acid manipulation, modification, and analytic approaches

• Viral and non-viral nucleic acid formulation and delivery

• Mammalian cell culture

• Quantitative analysis of biological molecules

• Critical data analysis, attention to detail, and troubleshooting abilities

• Written and oral presentation of results

• Manage and oversee CROs, providing technical expertise and direction on production and characterization activities

• Generate and support intellectual property generation for core projects

• Mentor and train research associates as needed

Minimum Qualifications:

• Ph.D. in Molecular Biology, Biochemistry, Bioengineering or related discipline

• Deep knowledge and understanding of RNA biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation

• Skilled in assay development and optimization of nucleic acid production, purification and biophysical characterization

• Execution focused, team oriented, and highly motivated

• Experience with the following techniques is highly preferred: RT-qPCR, RNA-seq, cloning, cell culture, immunohistochemistry, ELISA, ChIP, EMSA, FISH, Northern and Western blotting

Application instructions:

Apply to Flagship Pioneering

 

Company: VL50, Inc. 

Position: Molecular Biologist
Location: Cambridge, MA, US

 

About VL50, Inc.

VL50 Inc. is a privately held, well-funded, early-stage biotechnology company that is pioneering a novel transformative therapeutic approach.

VL50 was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics, Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (NASDAQ:SYRS), Rubius Therapeutics, Axcella Health, Evelo Biosciences, Kaleido Biosciences, and Indigo Agriculture. VL50 Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our development team.

Position Summary

VL50 is seeking a discovery biologist to join our expanding team as a part of our development group. The position requires broad technical experience that spans molecular biology, synthetic biology, and biophysics, with a strong emphasis on critical thinking, multitasking, and the ability to learn new techniques. The successful candidate will help lead and support multidisciplinary project teams focused on the engineering and development of new therapeutic modalities, including nucleic acids, peptides, proteins, cells, and various conjugate molecules. The candidate will focus on all aspects of development spanning conceptualization, experimentation, data analysis, presentation, and strategic planning.

Key Responsibilities

• Design, synthesis, and characterization of novel genetic and biological constructs, sensors, and circuits

• Mammalian cell culture

• Nucleic acid manipulation and associated analytic approaches

• Viral and non-viral nucleic acid formulation and delivery

• Quantitative analysis of biological molecules

• Critical data analysis, attention to detail, and troubleshooting abilities

• Written and oral presentation of results

• Manage and oversee CROs, providing technical expertise and direction on production and characterization activities

• Generate and support intellectual property generation for core projects

• Mentor and train research associates as needed

Minimum Qualifications:

• Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, Bioengineering, Engineering, Pharmaceutical Sciences or related discipline

• Deep knowledge and understanding of molecular biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation

• Proficiency in assay development and optimization of nucleic acid production, purification, and biophysical characterization

• Execution focused, team oriented, and highly motivated, with strong work ethic

• Experience with the following techniques is highly preferred: RT-qPCR, RNA-seq, cloning, cell culture, immunohistochemistry, ELISA, ChIP, EMSA, FISH, Northern and Western blotting

Application instructions:

Apply to Flagship Pioneering

Company: Anzu Partners

Position: Associate (Investment)
Location: Boston, MA, US; San Diego, CA, US; Washington, D.C., US

About Anzu Partners:

Anzu Partners is a venture capital and private equity firm that invests in breakthrough industrial technologies. We team with entrepreneurs to develop and commercialize technological innovations by providing capital and deep expertise in business development, market positioning, global connectivity, and operations. We focus on four key industrial areas: manufacturing, materials, monitoring and measurement, and modeling.

Anzu Partners has a strong track record of investing since its founding in 2014, and we have developed a robust team of investment professionals, technical specialists and operational support to drive results for our investors and portfolio companies. This October, we closed our first fund, Anzu Industrial Capital Partners, L.P., to invest in North American-based private industrial technology companies.

Our primary activities are: investing in and acquiring companies, and incubating our own business concepts with an in-house team. Our Associates go beyond typical roles of diligence and sourcing and will play a leading role in combining Anzu’s wide set of skills to deliver impact to our portfolio companies.

We focus on the US & Canada but will be opportunistically international when appropriate. We consider investments in a wide variety of situations, including early-stage (Seed, Series A and Series B), mature (strategic mergers and acquisitions), and special situations (corporate divestitures, public-take-private, distressed and turnaround).

Anzu Partners has investment offices in Boston, MA, San Diego, CA, and Washington, DC and Anzu’s finance and accounting operations are based in Tampa, FL.

About the Role:

Anzu is looking for a full-time Associate, who will be responsible for both investment and portfolio support.

Key activities in investment include:

• Conducting initial screening on potential investments

• Leading diligence with company, customer and competitor interviews when appropriate

• Analyzing financial projections and proposed deal terms

Key activities in portfolio support include:

• Building and testing prototypes for entry into new markets

• Analyzing product fit to the target market and any potential adjustments needed

• Developing commercial strategies (e.g. channels, pricing, etc.) for growing companies

The position reports to an Anzu Principal, or directly to a Managing Partner, depending on the situation as part of a small, cross-functional team with strong personal and professional development opportunities.

Qualifications

• Technical Master’s or PhD degree, with a focus on either Chemistry, Biology, or Computer Science strongly preferred.

• 1-4 years of work experience, with a preference for candidates with hands-on technical experience.

• Demonstrated strong academic ability.

• Strong personal drive and ability to operate independently when needed.

• Experience working with early-stage companies or startups preferred, but not required.

• Coding experience is a plus.

To Apply:

To express interest or to learn more, please send an up-to-date resume to wkp@anzupartners.com.

 

Company: Qiming Venture Partners

Position: The Mohamed Chaoui Venture Fellowship
Location: Palo Alto, CA, US; Cambridge, MA, US; Seattle, WA, US

Summary:

A former colleague of a Qiming US Partner and a true friend to the firm, Mohamed Chaoui, has recently passed away following a battle with lung cancer. He’s inspired us to create a rolling fellowship seeking to attract MBA, MD, Ph.D., PharmD or other advanced degree students with a unique Qiming US experience.

Mohamed’s multi-company and multinational career included banking, M&A, corporate finance, business development, general management overseeing biopharma affiliates and the Asia-Pacific operations, and for UCB, was instrumental in catalyzing the growth of their China operations. Mohamed was quick to understand early in his career that biotech and biomedical firms, many of which were venture-backed, could provide the means to discover, develop and commercialize transformational products in ways larger companies might fail. And very recently, he was instrumental as part of a small team in moving forward the initial venture funding efforts at UCB.

Mohamed was full of life, with a daring spirit, boundless energy and courage, abundant creativity, a clear sense of purpose aimed at patients, and a passion for pursuing innovation. At the same time, he was analytically superb, and constantly measured success in terms of shareholder and stakeholder value. For any of us that had the chance to work with him, his impact will never fade.

For these reasons, we’re in search of students seeking to use a semester or school break with a fellowship in Qiming’s US partnership. We commit to an experience that will provide a glimpse at what we do and how we work, help us answer questions or issues the partnership is facing, gain insights into young company creation coupled with product innovation, meet and work side by side with some very talented people and have what we hope is a fun and very memorable experience. In short, we’re hoping to provide you with something resembling working with Mohamed, and working on projects that we know he would cherish while adding value to Qiming and potentially, our growing network of portfolio companies.

About Qiming Venture Partners:

Founded in 2005, Qiming Venture Partners is a leading global venture capital firm with China offices in Shanghai, Beijing, Suzhou, Hong Kong and US offices in Palo Alto (CA), Cambridge (MA), and Seattle (WA). Qiming currently manages five US Dollar funds and four RMB funds with USD$2.7 billion assets

under management, with ~$1 billion in healthcare. Qiming is widely recognized as one of the top China venture firms consistently delivering top quartile returns to investors. In January 2017, Qiming initiated US Healthcare Fund I, with an investing strategy focused on US-based companies with strong market potential in China and close strategic links to Qiming China.

Position Summary:

Qualifications

  • Ph.D., M.D., MBA and/or PharmD degree with focus in life sciences required

  • Experience in a business setting beneficial (e.g. consulting, BD, finance)

  • Familiarity with China ecosystem and spoken language also beneficial but not required

  • Self-starter, ability to identify creative solutions independently

  • Strongcommunicationandpresentationskills

  • Passionforhealthcareinnovation

  • Fast learner with ability to get up to speed in technical areas outside core experience

  • Proficiency in Excel and PowerPoint

    Responsibilities

  • Conduct due diligence on potential investments independently and as part of core Qiming team

  • Present at internal investment committee as contributor to investment decisions

  • Strategic analysis of opportunity landscape incl. regulatory, scientific, clinical and IP

  • Evaluation of China opportunities for current and potential investment companies

  • Strategic and operational support to portfolio companies, as required

  • Source potential investment opportunities

Application Process:

The application is simple. Send us a one or two paragraph note telling us why you are interested in a venture experience, and what special abilities you’ll bring that can help us learn throughout a 3-4 month period with Qiming, in one of our 3 locations (Cambridge, Palo Alto or Seattle). Attach your CV, and tell us what timing is optimal within your academic timetable. Please send your application to: contact_UShealthcare@qimingvc.com.

 

Company: Merck Ventures

Position: Internship
Location: Amsterdam, NL

 

Position Summary:

We're looking for an analyst/intern to join our Merck Ventures Life Science investment team for 6 months in Amsterdam.

The internship provides a unique entrepreneurial opportunity for students to actively participate in and support the day-to-day operations of a venture capital fund. Additionally, the role allows establishing a good understanding of the international investor community in the life sciences field. This position is ideal for individuals interested in pursuing a career in consulting, strategy, venture capital, or entrepreneurship. As part of the internship, you will also be working with interns in the other Merck Ventures funds with the ability to broaden your horizon beyond Life Sciences.

Desired skills and experience:

- combined background and interest in (bio)pharmaceutical sciences or engineering and business (MD or PhD preferred but not a must)

- experience in finance or consulting is advantageous 

- passion for science - entrepreneurial drive to turn disruptive technologies to viable business 

- team player who knows that having fun and staying professional are not mutually exclusive

Must be eligible to do an internship in the Netherlands.

http://merck-ventures.com 

Application Instructions:

Applications should be sent directly (CV & cover letter) to Clemens Lakner (clemens.lakner@merck-ventures.com).

 

Company: 5AM Ventures

Position: 2018 Fellowship
Location: San Francisco, CA, US; Boston, MA, US

 

Company Summary:

5AM Ventures is an early-stage venture capital firm focused on building next-generation life science companies. Founded in 2002, 5AM Ventures has over $960 million under management.  The firm has offices in San Francisco, CA and Boston, MA. Formed by successful industry executives and experienced venture capitalists, the 5AM team takes a focused, hands-on approach to company building. In addition to leading investments and contributing as board members of its portfolio companies, 5AM is directly involved in company strategy, management recruiting, business development and fundraising and often takes short-term operating roles. In addition, 5AM has started ‘4:59’, an internal initiative focused on canvassing areas for science that may be ripe for building new companies.

Position Summary:

We are seeking a Fellow who can assist the 4:59 and 5AM teams with

1) reviewing new insights in prioritized areas of science to craft an investment thesis,

2) supporting scientific detailed diligence (e.g. research and talking to academics, KOLs), and

3) supporting new company formation activities with a focus on the scientific strategy.

Time commitment will be 20+ hours/ week, for 6 months. The firm is looking for an individual with strong scientific or medical background (MD and/or PhD) e.g. Post-docs, medical residents or fellows.

Application Instructions

To apply, please send C.V. to Applications@5amVentures.com by December 1st.

November 15, 2017

Company: Regeneron

Position: Pharmacogenomics Statistical Analyst
Location: Tarrytown, NY, US; Boston, MA, US (remote)

 

Position Summary
The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around
the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

Summary:
This position is responsible for performing association studies using genetic and genomic data, ranging from small candidate gene studies to larger genome-wide association studies (GWAS) in the support of clinical development programs. This position is part of the pharmacogenomics group, responsible for developing and implementing genetic/genomic strategies across all phases of clinical development and working across several therapeutic areas. This position requires frequent interactions with clinical teams and global project teams across Regeneron.

Duties:
This position is part of the pharmacogenomics group responsible for developing and implementing genetic/genomic strategies across all phases of clinical development and across several therapeutic areas. This position requires frequent interactions with biostatisticians, epidemiologists and clinical scientists to advise and plan statistical data analysis. This position also requires working in concert with other members of the Regeneron Genetics Center utilizing other large cohorts, datasets and analysis tools. The position will require significant cross-functional responsibilities, communicating results and findings to key internal stakeholders and external collaborators, so an ability to communicate very clearly is required.
Major activities:
     •     Design and conduct pharmacogenomic analysis studies: both candidate gene and genome-wide analysis
     •     Interface with clinical teams, research scientists, statisticians, and global project teams
     •     Provide statistical data interpretation and present data to internal stakeholders and project teams
     •     Publish key findings and attend conferences

Requirements:
     •     PhD in biostatistics, with a strong background in genetics or a PhD in genetics/molecular biology with MS in biostatistics
     •     Strong background in biostatistics and/or statistical genetics
     •     Strong background in genetics and/or molecular biology preferable
     •     Previous experience performing genetic association studies required
     •     Proficient in scripting and programming in R, Perl/Python in a Linux environment
     •     Proficiency working with and manipulating large genomic data sets, familiarity with statistical software (e.g., Plink, BCFtools,   
            SnpSift) for management/annotation/analysis of genomic datasets
     •     Experience working with Next-Generation Sequencing data preferable
     •     Broad scientific knowledge
     •     Experience in clinical development desirable
     •     Ability to work well in a team environment
     •     Excellent presentation and communication skills (essential)

APPLICATION INSTRUCTIONS:

Apply to careers.regeneron.com and search the req #10339BR or follow this direct link: https://careers.regeneron.com/job/REGEA0026304107/Pharmacogenomics-Statistical-Analyst

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron’s unwavering commitment to combining good science & good business.

 

October 28, 2017:

Company: nference

Position: Computer/Data Scientist & Research Scientist 

Company Description: The world's biomedical knowledge is huge, and it keeps growing exponentially; each of can only read the small and ever-shrinking fraction of the existing documents pertinent to our work. To tackle this problem, nference leverages machine learning for the real-time automated extraction of knowledge from the commercial, scientific, and regulatory bodies of literature. Importantly, we pair our MIT/Stanford/Harvard trained AI and data science team with clinical scientists from the Harvard-MIT MD/PhD program and genomics experts from the Broad Institute to both identify translationally relevant questions and triangulate results to these queries using molecular analytics (genomics, transcriptomics, proteomics, etc) and other public and proprietary datasets.  This approach allows our firm to offer a diverse set of applications ranging from R&D to commercial strategy and operations in the life sciences ecosystem. Pay is competitive, and although nference is seeking full-time employees, we are open to hiring part-time employees and interns. Website: nference.ai

Position Description: Computer/Data Scientist  

We are seeking computer/data science experts to help advance the design, development, and engineering of the rapidly growing spectrum of client-facing UIs for nferX (nference's knowledge synthesis platform). You will also build custom applications to analyze and visualize public and proprietary datasets, and integrate these data with existing nferX infrastructure. JavaScript and Python experience highly preferred. Interested applicants should email an introduction with a resume/portfolio to Mark Kalinich (mark@nference.net). 

Position Description: Research Scientist

We are seeking bioengineers, systems biologists, and bioinformatics experts to leverage the nferX platform to identify novel and translationally significant findings from our knowledge synthesis platform and validate these results through the analysis of both public and proprietary structured datasets (genomic/transcriptomic/proteomic data, drug screens, etc.). Research areas will be project-focused, and successful applicants should expect to present to both the nference team and our clients. Basic coding experience not required, but preferred. Interested applicants should email an introduction and resume/CV to Mark Kalinich (mark@nference.net)

 

September 1, 2017:

Company: Hamilton Brook Smith Reynolds

Position: Patent Attorney or Patent Agent (Biotechnology)

You can have it all! Be part of a dynamic IP practice. Build strong relationships with colleagues and clients. Contribute to deeply meaningful and interesting work in a collaborative, team environment. And enjoy unparalleled work and home life balance.

We seek an associate with 2-4 years of patent prosecution experience and an advanced degree in immunology, molecular biology, genetics, biochemistry, or related discipline. The successful candidate will have a minimum of 2 years of patent drafting and prosecution experience for U.S. and foreign clients, and an advanced degree, Ph.D. preferred. Registration with the USPTO and outstanding writing and interpersonal skills required. J.D. from an accredited law school preferred.

Hamilton Brook Smith & Reynolds offers a competitive salary, top-flight benefits and is the firm that will allow you to make the most of your education and experience, while enjoying a superior work and home life balance in Boston or the beautiful Boston suburb of Concord.

If you would like to step out of the pack and into a highly visible role on our dedicated team, please send your resume and cover letter to:

Director of Human Resources
Hamilton, Brook, Smith & Reynolds, P.C.
530 Virginia Road, PO Box 9133
Concord, MA 01742-9133
OR email: legal.recruitment@hbsr.com
978.202.3461
Please see our website at www.hbsr.com.

August 25, 2017:

Company: Wolf Greenfield

Position: Technology Specialist*

*Please note that we do not have any current openings in the Biotech practice. However, we anticipate hiring in mid-2018.

What is a technology specialist? In the legal world, a technology specialist (tech spec) is an individual whose educational background is in science or engineering and decides to embark on a career in patent law.  Having a robust background in science or engineering is essential for anyone interested in pursuinga career in patent law. What is not required is prior legal experience or a degree in law. All that is required is a strong foundation in engineering or science, a love of learning new technology and a passion for working with others.  Typical responsibilities of our tech specs include:

•           Reviewing technical disclosures and participating in client interviews to understand new inventions;

•           Searching literature and patent databases to determine the patentability of inventions;

•           Drafting written assessments of the prospects of obtaining patent protection;

•           Writing patent applications;

•           Preparing responses to communications from the U.S. Patent and Trademark Office;

•           Developing arguments for patentability to Patent Office Examiners; and

•           Reviewing patents as part of the IP due diligence for a potential acquisition or merger.

Technology Specialists at Wolf Greenfield pursue one of two tracks:

•           Patent Attorney Track:  After at least one year with the firm gaining valuable on-the-job experience, we anticipate that you will enroll in a part-time law school evening program.  The firm supports your education by reducing your billable hour requirement and covering the cost of tuition and books.  The part-time law school program typically takes four years to complete.  Upon graduating, taking the bar exam, and being admitted to practice law, you will transition to the role of Associate.

•           Patent Agent Track:  On the Patent Agent Track, you will enjoy the same types of challenging work and professional development opportunities, with a reduced billable hour requirement.  Your training and on-the-job experience will help you develop your career as a seasoned Patent Agent.  The opportunity to participate in the firm's law school program will not be offered to someone in this position.

Qualifications: Candidates must have an advanced degree in biology, biochemistry, microbiology, genetics, molecular biology, biological sciences or a related discipline.

To view our current openings, please visit http://www.wolfgreenfield.com/careers/technology-specialists/current-openings. Questions? Email us at legal.recruiting@wolfgreenfield.com.