Rejuvenate Bio

Senior Synthetic Biology Scientist

At Rejuvenate Bio, we aspire to treat aging and age related diseases of animals and humans. We are a spinout from George Church's lab at Harvard Medical School and the Wyss Institute, and our goal is to treat pets with targeted gene therapies directed at curing specific disease states associated with old age that also have the potential to extend overall health and maximal lifespan.

Duties & Responsibilities

Rejuvenate Bio is looking for a highly-motivated individual to join our energetic team and accelerate development of our therapies. The Scientist position will directly support efforts to drive forward our future commercial offerings. The applicant will be tasked with their own project area and will assist with virus creation and running assays. Specifically, they will create a new inducible system compatible for use in AAV gene therapies. The role reports to the CSO of Rejuvenate Bio.

Responsibilities will include:

  • Setting, completing and updating milestones related to main project.

  • Development of assays, techniques, and procedures.

  • Performing directed evolution experiments

  • Conducting ligand binding assays

  • Executing experiments, independently and in conjunction with a small team in support of research studies

  • Following laboratory protocols and safety regulations.

  • Performing detailed and accurate documentation of all experiments and laboratory practices.

  • Accountable for on-time, high quality results and clearly communicating progress.

Basic Qualifications

Ph.D. in biology, biochemistry, microbiology, biomedical engineering, bioengineering or related field required. At least five years of mammalian cell culture experience (splitting cells, transfection, etc), basic cloning techniques (restriction enzyme, gibson, golden gate, or gateway) or related experience required. Graduate school counts toward years of experience.

Additional Qualifications

2+ years of postdoc experience preferred. Experience with synthetic biology, directed evolution, protein engineering, library preparation and barcoding, screening methodologies, and next gen sequencing. Computation experience: analyzing next gen sequencing results and basic machine learning techniques. Willingness to work outside of his/her discipline to accomplish project goals. Excellent molecular biology and microbiology skills. Experience with flow cytometry, ELISAs, PCR, and microscopy. Proven ability to draft and implement lab protocols. Ability to work independently as well as in a collaborative team environment. Strong work ethic, communication skills and goal-oriented personality.

If interested email jobs@rejuvenatebio.com with a resume and cover letter. We are located in San Diego California.

Harvard OTD Business Development Fellowship

If you are interested in a career in technology transfer, intellectual property, or business development, this fellowship will provide a practical introduction to the skills necessary to be successful in these fields.

To be eligible, applicants must be Harvard Ph.D. students or postdocs and must have completed qualifying exams. All fellows must be able to commit five hours per week for one year. Selected fellows will be required to attend OTD's Bench-to-Business Boot Camp on May 1 – 2, 2019.

Important recruitment dates (2019)

Please note, these dates reflect revisions made in January 2019.

  • January 25: Applicants express intent to apply for the Fellows program by submitting a résumé and cover letter to Tyler Brown, senior fellow

  • February 1: A select group of applicants will be asked to complete a case study

  • February 18: Completed case study due

  • March 11: Next-round interviewees notified

  • Week of March 25: Interviews conducted

  • April 3: Accepted Fellows notified

  • May 1-2: Bench-to-Business Boot Camp takes place at Harvard Medical School

  • Mid-May: Work begins

How to apply

Interested PhD students and postdocs should submit a résumé and cover letter to senior fellow Tyler Brown, expressing interest in the OTD Business Development Fellows program, by January 25. OTD will then provide a select group of applicants with a commercialization case study on February 1, to be completed by February 18.

Questions? Please contact Tyler Brown at tylerbrown@g.harvard.edu.

Celdara Medical

Scientist

POSITION DESCRIPTION

Celdara Medical, LLC (CM) is building a portfolio of early-stage therapies. Each of these is at a different stage of development with a different development path, but all aim to save lives and/or improve quality of life.

CM is seeking an outstanding individual with a strong background in biomedical science to work with the scientific team on a variety of technical and strategic initiatives. Applicants require demonstrated technical experience in the field, ie: a minimum of 5 years of full time laboratory experience.

We love data, data comes from the lab, and this is a lab position where the rigorous generation of high quality – and sometimes regulated – data is the measure of success. Successful candidates will thrive on collaboration and a in a team-based environment.

 

KEY RESULT AREAS

Support the Research and Development goals of the organization:

  • Perform multiple experimental assays and maintain relevant lab samples and materials

  • Analyze, synthesize, and communicate data to both technical and non-technical colleagues and collaborators

  • Write, maintain, and troubleshoot experimental protocols

QUALIFICATIONS

  • Integrity, i.e. commitments must be bankable

  • Strong sense of responsibility for deadlines and accurate data

  • Ability to deliver results in a highly independent environment

  • Rigor and attention to detail in all aspects of science

  • Demonstrated laboratory experience with:  Cell culture, protein analysis, flow cytometry, immunoassays, protein production and purification

  • Flexibility and mental agility

  • Enjoyment of diverse areas of science

  • Excellent time-management skills

  • Strong spoken and written communication skills

  • Enjoy collaboration and a team-based environment

  • Bachelor’s degree in scientific or medically-relevant field

  • Broad knowledge of laboratory techniques and/or other specialized knowledge

  • Work authorization

 

ABOUT CELDARA MEDICAL

Celdara builds academic and early-stage inventions into high-potential medical companies. We identify technologies with exceptional clinical potential, build businesses around them in close collaboration with their inventor(s), and spin out daughter companies for trade sale or A round investment.

APPLY

Please send your cover letter and resume to hr@celdaramedical.com.

Beam Therapeutics

Scientist, New Opportunities

Beam seeks an experienced scientist to help us advance our New Opportunities programs, including discovering and validating the technical feasibility of novel genomic edits to disease-causing mutations with the ultimate goal of creating new therapeutic programs. The ideal candidate will be a self-motivated, technically competent scientist that is energized to join a small, fast-moving team.

Primary Responsibilities:

  • Critically evaluate and apply new base editor constructs to prospective disease targets.

  • Generate model cell lines for novel genetic targets and optimize on-target editing efficiencies.

  • Work with teams in specific therapeutic areas to translate editing to therapeutically-relevant cell types.

  • Design and implement cloning strategies to construct plasmids for the production of mRNA, protein, and recombinant

  • AAV reagents used in editing experiments.

  • Implement novel and established assays to assess large-scale genomic rearrangements and off-target effects of base editing technologies.

  • Design and execute DNA/RNA purification and quantification assays (qPCR, ddPCR and RNA-seq).

 

Qualifications:

  • PhD in biochemistry, molecular biology or related discipline.

  • Previous lentiviral production experience.

  • Experience culturing and transfecting common cancer cell lines such as HEK293T and U2OS. Experience culturing iPS cells is a plus.

  • Experience with molecular cloning techniques such as Gibson and USER assembly strongly preferred.

  • Experience using emerging technologies such as high-throughput sequencing and droplet digital PCR.

  • Ability to design experiments, analyze data and interpret results independently and within a small, dynamic group of peers.

  • Critical and creative thinking.

Directions to apply 

Submit your resume to careers@beamtx.com

Any interested parties can contact directly Jason Gehrke at jgehrke@beamtx.com: “This is an excellent opportunity for students coming straight from a PhD program to get in at the scientist level. It's worth noting that we're also recruiting at the Master level as well”.

2019 Kleiner Perkins Product & Design Fellows and Biotech Entrepreneurs

Applications for the KP Product Fellows Program and the KP Design Fellows Program are now open on http://fellows.kleinerperkins.com/


Here are some details on the program -

  • An exciting summer internship at one of our companies like Uber, Doordash, Robinhood and Shape Security for summer work experiences (for Design) and a full-time role (for Product)

  • Exclusive access to events and programming with our partners at Kleiner Perkins, CEO’s and executives across a variety of our portfolio companies

  • Fun social events like sailing to Angel Island, kayaking and paintball

  • An opportunity to connect with some of the brightest entrepreneurs across the country wanting to make an impact in San Francisco and Silicon Valley

  • 100K seed funding from Kleiner Perkins for Fellows who found their own companies. See blog post.

 

Here are a couple of quick videos to learn more about the summer:

KP Fellows Program

KP Fellows and Slack CEO Stewart Butterfield

Making an Impact


Applications for the 2019 KP Design Fellows Program and KP Product Fellows Program are open now and close January 31st, 2019 at 11:59PM on fellows.kleinerperkins.com.  The answer to most FAQ's can be found here. But if you have any other questions please feel free to reach out to Alicia from Kleiner Perkins at alicia@kleinerperkins.com.

FL62, Inc.

Company Overview

FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.

Position Summary

The (Sr.) Microbiologist will be primarily responsible for developing FL62’s biological delivery tools utilizing diverse microbes. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.

Key Responsibilities:

  • Design and execute experiments to validate the FL62 platform

  • Develop methods to repurpose microbe-host interactions

  • Work with senior leadership to develop and execute the scientific vision

  • Collaborate with CROs and other outside entities

  • Manage and mentor a team of junior scientists and RAs

Required Skills/Experience:

  • PhD and 2 yrs of postdoc or industrial experience in bioengineering, microbiology, or chemical engineering

  • Excellent understanding of host-microbe interactions, including secretion systems, secreted molecules, and surface protein interactions.

  • Experience with plant, fungal, or mammalian host-microbe interaction research

  • Experience growing and engineering diverse bacteria including E. coliPseudomonas,

    XanthomonasSalmonella, and Serratia.

  • Experience developing auxotrophic versions of the above species

  • Experience with inducible gene expression vectors

  • Experience producing bacteria in benchtop and laboratory-scale fermentation reactors

  • Experience with filtration and purification technologies, such as ultracentrifugation,

    tangential flow filtration, or irradiation.

  • Experience with novel assay development including reporter assays, molecular, and

    immune assays.

  • Excellent verbal and written communication skills

  • Strong organizational skills

  • Ability to work in a fast-paced and quickly changing environment

Desired Skills/Experience:

  • Experience engineering bacterial surface proteins or secreted effector proteins

  • Experience moving heterologous systems into model bacteria (e.g. E. coli)

  • Experience with extremophiles, cyanobacteria, or magnetotactic bacteria

  • Experience collecting human (e.g. fecal) and/or environmental (e.g. soil) bacterial

    isolates

  • Experience with studying microbe virulence factors

  • Experience working on bacterial energetics or flux analysis

If you are interested please reach out to David Kolesky directly: dkolesky@flagshippioneering.com.

FL62, Inc.

Company Overview

FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.

Position Summary

The (Sr.) Microbial Engineer will be primarily responsible for the design, testing, and analysis of new delivery modalities. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.

Key Responsibilities:

  • Design and execute experiments to validate the FL62 platform

  • Develop methods to produce and characterize bacterial products

  • Work with senior leadership to develop and execute the scientific vision

  • Collaborate with CROs and other outside entities

  • Manage and mentor a team of junior scientists and research associates

  • Oversee molecular biology assay development.

Required Skills/Experience:

  • PhD and 2 yrs of postdoctoral or industrial experience in bioengineering, microbiology, or chemical engineering

  • Experience growing and engineering diverse bacteria including E. coliPseudomonas,XanthomonasSalmonella, and Serratia

  • Experience developing auxotrophic versions of the above species

  • Experience with modern large-scale knockout creation methods, such as CRISPR and

    lambda red recombineering

  • Experience working on bacterial energetics or flux analysis

  • Experience producing bacteria in benchtop and laboratory-scale fermentation reactors

  • Experience with filtration and purification technologies, such as ultracentrifugation,

    Tangential Flow Filtration, or irradiation.

  • Excellent verbal and written communication skills

  • Strong organizational skills

  • Ability to work in a fast-paced and quickly changing environment

Desired Skills/Experience:

  • Experience studying or modulating host-microbe interactions, including virulence, secretion systems, secreted toxins, and surface protein interactions.

  • Experience with plant, fungal, or mammalian host-microbe interaction research

  • Experience developing assays for novel synthetic biology applications

  • Experience with high throughput screening technologies

  • Experience with synthetic biology gene circuits

If you are interested please reach out to David Kolesky directly: dkolesky@flagshippioneering.com.

CRISPR Dx

Scientist I, Molecular Diagnostics Platform Innovation

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding scientist to work as part of a creative team dedicated to feature development and expansion of a leading molecular diagnostic technology platform. The successful candidate will contribute to driving the technology forward through innovations that will boost overall performance and robustness of the company’s CRISPR diagnostic platform.

The ideal candidate will have prior experience designing, developing, testing, implementing, and supporting molecular diagnostics assay workflows in a research or industrial environment. Experience working on diagnostics, in particular platform technologies, on cross-functional teams with success translating developments into product features is highly valued. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR- based platform for molecular diagnostics.

Duties and Responsibilities Include:

  •  Provides substantial, high-quality contributions to projects by working independently and leveraging the active support of others

  •  Independently identifies and utilizes relevant internal documentation and external publications to optimize procedures and processes

  •  Proactively and effectively interacts with counterparts across one or more departments to support achievement of project goals

  •  Creative problem solving and critical thinking skills for addressing technical issues during assay development

  •  Helps to design effective protocols to rapidly improve overall diagnostic performance

  •  Develops methods to translate platform improvements into solutions for IVD products that can

    be scaled for manufacturing

  •  Performs molecular laboratory methods including nucleic acid extraction, reverse transcription, quantitative PCR, and various other molecular diagnostic technologies.

Minimum Qualifications

  •  Master’s degree (+1 year relevant experience) or Bachelor’s degree (+3 years relevant experience) in molecular biology, biochemistry, bioengineering, biomedical engineering, chemical engineering, or a closely-related discipline is required; PhD preferred

  •  Experience with optimizing molecular diagnostics techniques

  •  Experience with data analysis, maintenance of data quality and technical troubleshooting

Experience

  •  Demonstrated ability to contribute effectively to cross-functional process development, improvement, and troubleshooting teams

  •  Strong written and oral communication skills with demonstrated track record of successful communication with internal teams and managers

  •  A track record of successfully completing assignments and meeting goals within aggressive timelines

  •  Knowledge of statistical process control charts and data interpretation

  •  Excellent organizational and planning skills

Please reach out to crisprdx@gmail.com with any questions.

CRISPR Dx

Research Technician, Molecular Diagnostics

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding technician to work as part of a dynamic team to develop and launch molecular diagnostic products. The successful candidate will execute studies, conduct data analysis, and document results. This role will interact with other groups and functionalities in the research and product development teams. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR-based platform for molecular diagnostics.

Responsibilities:

  • Contributes to experimental design, data analysis, critical thinking, and problem-solving to improve methods or procedures.

  • Conducts laboratory and study activities according to approved study protocols, Standard Operating Procedures (SOPs), and Work Instruction Documents (WIDs) to maintain the safety of self and colleagues and the integrity of the data collected.

  • Proficient at carrying out assignments with general guidance in planning, organizing and meeting deadlines.

  • Supports an atmosphere of inclusion and collective contribution to projects and procedures with team. Communicates regularly with supervisor to relay project progress, experiment results, and data analysis, and discuss challenges

  • Good documentation is essential to this position and includes recording all work, notebooks and other documentation for assigned projects/experiments

Skills and Experience:

  •  B.S or M.S. degree in Biology, Biochemistry, or related field or comparable industry experience

  •  0-2 years industry experience (IVD a plus)

  •  Knowledge and laboratory experience with molecular biology techniques. Strong analytical

    and quantitative skills.

  •  Excellent oral and written communication skills

  •  Capable of adjusting to dynamic working environment and changing priorities, while ensuring

    timely completion of assigned tasks

Please reach out to crisprdx@gmail.com with any questions.

CRISPR Dx

Scientist I, Molecular Diagnostics

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding scientist to work as part of a product development team to engineer and launch molecular diagnostic products across a range of impactful healthcare applications. The successful candidate will contribute to new product initiatives through requirement definition, prototype design, reaction optimization, verification, validation, and assay troubleshooting.

The ideal candidate will have prior experience designing, developing, testing, implementing, and supporting molecular diagnostics assay workflows using a requirement-driven approach – equivalent academic experience is highly valued and will qualify. Experience working on cross-functional teams to apply scientific methods and product/process design principles in establishing and improving quality control and manufacturing processes is a plus. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR-based platform for molecular diagnostics.

Duties and Responsibilities Include:

  •  Provides substantial, high-quality contributions to projects by working independently and leveraging the active support of others.

  •  Independently identifies and utilizes relevant internal documentation and external publications to optimize procedures and processes.

  •  Creative problem solving and critical thinking skills for addressing technical issues during assay development

  •  Proactively and effectively interacts with counterparts across one or more departments to support achievement of project goals.

  •  Helps to design guard-banding parameters, verification tests and validation experiments

  •  Performs primary data analysis of results, and provides substantial contributions to internal

    technical reports and design documentation

  •  Writes and reviews experimental protocols and Standard Operating Procedures, incorporating

    input from other team members efficiently and effectively

  •  Performs molecular laboratory methods including nucleic acid extraction, reverse transcription,

    quantitative PCR, and various other molecular diagnostic technologies.

  •  Participates in cross-functional process development and improvement teams focused on

    improving efficiency, throughput, cost, and quality

Minimum Qualifications

  •  Master’s degree (+1 year relevant experience) or Bachelor’s degree (+3 years relevant experience) in molecular biology, biochemistry, bioengineering, biomedical engineering, chemical engineering, or a closely-related discipline is required; PhD preferred.

  •  Experience with data analysis, maintenance of data quality and technical troubleshooting.

Experience

  •  Demonstrated ability to contribute effectively to cross-functional process development, improvement, and troubleshooting teams.

  •  Strong written and oral communication skills with demonstrated track record of successful communication with internal teams and managers.

  •  A track record of successfully completing assignments and meeting goals within aggressive timelines.

  •  Knowledge of statistical process control charts and data interpretation.

  •  Excellent organizational and planning skills.

Please reach out to crisprdx@gmail.com with any questions.

CRISPR Dx

Director of Assay Development, Molecular Diagnostics

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding Director of Assay Development to lead product development teams to engineer and launch molecular diagnostic products. The successful candidate will be responsible for strategic direction of new products, planning and execution of research and development activities. In addition, the successful candidate will help drive the innovation of the platform and translate improvements into new products. This role provides strategic and technical leadership in defining and achieving product development objectives while ensuring compliance with health authority requirements. The Director of Assay Development is also responsible for partnering with life cycle teams and internal as well as external business partners to drive product development. This role will drive continuous improvement within product development processes and manage resources to achieve business results within budget. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR-based platform for molecular diagnostics.

Duties and Responsibilities include:

  •  New Product Planning – Interacts with Marketing to set product specifications, timing, resources and provide technical expertise.

  •  Oversees critical reagent development, validation, and transfer to Operations.

  •  Project Management – Oversees the management of cross-functional teams in the development

    and commercialization of reagent applications and new product development.

  •  New Product Development – Conducts feasibility studies. Develops reagents within design

    control process and oversees validations. Oversees research and development of new products,

    as well as the transfer of products to Operations.

  •  Directs analytical studies for Marketing and FDA approval and ensures GMP, ISO and IVDD

    compliant documentation.

  •  Addresses strategic and technical issues; prepares departmental budgets; monitors department

    spending.

  •  Directs departmental staff including: interviewing and hiring staff, providing performance

    feedback and reviews, counseling, developing, rewarding, completing progressive disciplinary

    and terminating.

  •  Monitors work to ensure quality, and continuously promote First Time Quality.

  •  Responsible for employee development including leaders and all level of scientists in the

    organization. Responsibilities also include developing workforce planning models and developing skills sets within team to meet future technology requirements

Minimum Qualifications:

M.S. in a Life Sciences Discipline (Biochemistry/Immunology/Pathology/Molecular Biology). PhD preferred, or equivalent experience.

Experience:

  •  With MS in Life Sciences: Eight (8) years combined academic and industry with direct experience in an IVD company.

  •  With PhD in Life Sciences: Six (6) years combined academic and industry with direct experience in an IVD company.

  •  4 years of management experience.

  •  Experience working with Marketing, Quality Assurance and Operations.

  •  Demonstrated record of accomplishments (e.g., publications in scientific journals, issued US

    patents).

Preferred Qualification:

8+ years of management experience

Knowledge, Skills, and Abilities:

  • Strong background in assay development, including immunoassay and immunohistochemistry or in situ hybridization and nucleic acid detection.

  • Demonstrated knowledge of cell biology, pathology, histology, molecular biology, chemistry, or biochemistry. Experience with immunohistochemistry preferred. Must demonstrate technical aptitude to learn different scientific applications quickly.

  • Experienced in IVD product development and FDA submissions.

  • Excellent leadership and communication skills, creative problem solver especially in technical areas.

  • Familiarity with the various regulatory requirements (GMP, ISO and IVDD).

  • Must work well with cross functional teams.

Please reach out to crisprdx@gmail.com with any questions.

Regeneron Pharmaceuticals

Job Title: Immuno-oncology Scientist

Location: Tarrytown, NY (near New York City)

Requisition Number: 14586BR

 

Company Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Visit us at www.regeneron.com .

Summary

The successful candidate will directly contribute to the development of novel antibody therapeutics to treat a variety of malignancies in patients. This candidate will join a dynamic, high-profile, and multidisciplinary team that studies an array of anti-tumor immunotherapies including checkpoint inhibitors.


The scientist will be responsible for validating our expanding portfolio of antibodies that have been engineered to engage a variety of immune effector pathways, including co-stimulatory signaling. Specifically, this candidate will develop novel animal models to conduct complex in vivo and ex vivo murine tumor studies to test rational combinations of cancer therapeutics with the goal of advancing leads to the clinic.


The qualified individual will have a strong background in one or more areas of tumor biology, immunology, oncology, and/or immuno-oncology.


Ideal applicants will possess excellent interpersonal and communication skills, as this candidate will be expected to work productively in a collaborative, cross-functional team environment. 


Further, critical problem-solving abilities and a commitment to scientific excellence are desired.

Responsibilities
• Design, plan, and independently perform complex anti-tumor efficacy studies in mice including: cell culture, dosing (IV, SC, IP), and measuring tumors, as well as the dissection of immune organs for subsequent ex vivo analysis.
• Develop novel murine models to investigate combinatorial immuno-therapeutic strategies
• Design flow cytometry (FACS) panels and perform FACS analysis on human and murine cells, tumors, and tissues
• Synthesize results across experiments and programs in PowerPoint presentations and present to colleagues and senior management, including clinical and regulatory teams.
• Responsible for authoring documents to be published in regulatory filings, patent applications, external conference posters, and journal articles.
• Work successfully in cross-functional teams by contributing data and ideas
• This Scientist position comes with the potential to manage Research Associates

Requirements

This position requires a minimum of a Ph.D, and experience in the below:
• Skilled in the design of complex studies to interrogate in vivo efficacy of novel therapies.
• Ability to independently perform in vivo efficacy studies in both immunocompetent and immunocompromised mice (tumor implantation, monitoring tumor growth by caliper or bioluminescence (IVIS), and monitoring survival)
• Skilled in ex vivo and in vitro techniques, including the culture of human and mouse cells and the analysis of serum cytokine levels
• Skilled in development and design of FACS antibody panels and analysis of FACS data
• Demonstrated interpersonal and written/oral communication skills


This position will require the individual to pass a physical before beginning employment.


This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry.

Apply today https://careers.regeneron.com/job/REGEA0026307066/Immuno-oncology-Scientist  and learn more about Regeneron’s unwavering commitment to combining good science & good business. 

Qiming Venture Partners

Qiming Venture Partners USA, The Mohamed Chaoui Venture Fellowship 2019

www.qimingvcusa.com

The Mohamed Chaoui Venture Fellowship: A fellowship for those of you seeking the challenge of a career in venture capital.

A former colleague [of a Qiming US partner] and a true friend to the firm, Mohamed Chaoui, recently passed away following a battle with lung cancer. He has inspired us to create a fellowship to help develop MBA, MD, Ph.D., PharmD or other advanced degree candidates with a unique Qiming US experience.

Mohamed’s multi-company and multi-national career included banking, M&A, corporate finance, business development, general management overseeing biopharma affiliates, and for UCB, was instrumental in catalyzing the growth of their China operations. Mohamed was quick to understand early in his career that biotech and biomedical firms, many of which were venture-backed, could provide the means to discover, develop and commercialize transformational products. Mohamed was full of life. He had a daring spirit, boundless courage, abundant creativity, passion for pursuing innovation, and most importantly, a clear sense of purpose to patients. For any of us that had the chance to work with him, his impact will never fade.

For these reasons, we have created a fellowship to honor our colleague and friend. We commit to an experience that will provide a glimpse at how we work, help us answer important questions, gain insight into young company creation, work side-by-side with very talented people and have a memorable experience.

Qualifications
• Ph.D., M.D., MBA and/or PharmD degree with focus in life sciences required
• Experience in a business setting beneficial (e.g. consulting, BD, finance)
• Familiarity with China ecosystem and spoken language beneficial but not required
• Self-starter, ability to identify creative solutions independently
• Strong communication and presentation skills
• Passion for healthcare innovation
• Fast learner with ability to get up to speed in technical areas outside core experience
• Proficiency in Excel and PowerPoint

Responsibilities
• Conduct due diligence on potential investments independently and as part of core Qiming team
• Present at internal investment committee as contributor to investment decisions
• Strategic analysis of opportunity landscape incl. regulatory, scientific, clinical and IP
• Evaluation of China opportunities for current and potential investment companies
• Strategic and operational support to portfolio companies, as required
• Source potential investment opportunities

Application process

The application is simple. Send us a one or two paragraph note telling us why you are interested in the role, and what special abilities you’ll bring that can help us develop throughout a 3-4 month period with Qiming, in one of our 3 locations (Cambridge, Bay Area or Seattle). Attach your CV, and tell us what timing is optimal in 2019. Please send your application to: contact_UShealthcare@qimingvc.com.

64-x

Company Website: https://www.64-x.com/

We founded 64-x with the mission to engineer microbes that solve longstanding problems in biomanufacturing, bioremediation & health. We’re looking for creative thinkers that are passionate about making this vision a reality. We are a team of founders from Harvard, Yale, and the Wyss Institute of Biologically Inspired Engineering, backed by leading venture funds such as Y Combinator, First Round Capital and SV Angel. We have many positions open, from strain engineering to business development. If you want to be a part of an energetic and collaborative team with an impactful mission, join us. We're really excited to meet you!

Positions Available:

1. Scientist - Microorganism Engineering: We’re looking for a highly motivated and talented scientist to lead our microorganism engineering team. This scientist will lead the development of a novel class of bacterial organism “chassis” with the potential to address longstanding problems in bioremediation, biomanufacturing and health. 

2. Scientist - Strain Engineering: We’re looking for the best scientists to join our strain engineering team. These scientists will work closely with our microorganism engineering team, and use novel bacterial chassis to both generate and characterize new strains with targeted characteristics. 

**If you don't see a perfect match or just want to learn more, send us a message at careers@64-x.com!

Link to job postings:

https://angel.co/64minusx/jobs 

Sanofi

Position Title: Postdoctoral Fellowship: Lipidomics

Location: Waltham, MA

A Post Doctoral Scientist is needed to participate in development and application of a cutting edge lipidomics platform for biochemical fingerprinting of biological samples and identification of the disease biomarkers. It will support implementation of a novel approach to drug discovery and development based on translational biomarkers by identification of lipids associated with progression of disease. The work will include testing of innovative approaches for designing longitudinal studies, selection of appropriate controls and normalization approaches for identification of disease progression lipid biomarkers.

Qualifications:

  • PhD from an accredited university in Analytical Chemistry or related field

  • Experience with LC-MS, High resolution mass spectrometry and analysis of lipids

  • Must have US work authorization



Please click here for more information.

Sanofi

Position Title: Postdoctoral Fellowship: Bioprocess Analytics

Location: Framingham, MA

We are looking for candidates for an exciting post doc position to join our Bioprocess analytics team. The ideal candidate will join a dynamic and PAT motivated team and will serve as a key subject matter expert supporting bioprocess process development, data analytics and statistics process control

We are looking for candidates for an exciting post doc position to join our Bioprocess analytics team. The ideal candidate will join a dynamic and PAT motivated team and will serve as a key subject matter expert supporting bioprocess process development, data analytics and statistics process control activities using vibrational spectroscopic technologies.  

Major Job responsibilities:

  • Invisible to visible spectral characterizations of CQAs using pattern recognition, artificial intelligence, machine learning and established pleiotropic network of biomolecules.

  • Analyze large data sets which include real-time bioprocess data and offline analytical data sets.

  • Characterizations and interpretations of cell culture’s critical quality attributes (CQAs) and parameters using UV, Raman, FTIR, Imaging, florescence and FBRM spectroscopy. 

  • Develop Chemometrics data analysis concepts and modeling in support of batch and continuous manufacturing.

  • Develop a Chemometrics predictive modeling platform, exploratory data analysis, Chemometrics model development, validation and model maintenance.

Basic Qualifications:

  • PhD from an accredited university in Process Spectroscopy, Chemometrics, chemical engineering or process engineering

  • Expertise in developing, interpreting, implementing and managing vibrational or other spectroscopic techniques such as FTIR, NIR, Raman, Imaging, florescence and FBRM or related techniques with a strong publication record

  • Strong expertise on Chemometrics data modeling combined with invisible to visible modeling concept using Bioprocess data

  • Expertise on machine learning, neural networks, clustering, pattern recognition, probability, supervised and unsupervised data modeling

  • Outstanding experience on upstream, downstream bioprocess and cell culture data mining

  • Expertise in analyzing mass spectrometric, chromatographic, thermal and genomic data analysis using machine learning and support vector machine

  • Advance skills with R, C++, and MATLAB/Simulink, and Neuron

  • Must have US work authorization

Preferred Qualifications:

  • PAT implementations in continuous manufacturing environment is plus

Please click here for more information.