Beam Therapeutics

Scientist, New Opportunities

Beam seeks an experienced scientist to help us advance our New Opportunities programs, including discovering and validating the technical feasibility of novel genomic edits to disease-causing mutations with the ultimate goal of creating new therapeutic programs. The ideal candidate will be a self-motivated, technically competent scientist that is energized to join a small, fast-moving team.

Primary Responsibilities:

  • Critically evaluate and apply new base editor constructs to prospective disease targets.

  • Generate model cell lines for novel genetic targets and optimize on-target editing efficiencies.

  • Work with teams in specific therapeutic areas to translate editing to therapeutically-relevant cell types.

  • Design and implement cloning strategies to construct plasmids for the production of mRNA, protein, and recombinant

  • AAV reagents used in editing experiments.

  • Implement novel and established assays to assess large-scale genomic rearrangements and off-target effects of base editing technologies.

  • Design and execute DNA/RNA purification and quantification assays (qPCR, ddPCR and RNA-seq).

 

Qualifications:

  • PhD in biochemistry, molecular biology or related discipline.

  • Previous lentiviral production experience.

  • Experience culturing and transfecting common cancer cell lines such as HEK293T and U2OS. Experience culturing iPS cells is a plus.

  • Experience with molecular cloning techniques such as Gibson and USER assembly strongly preferred.

  • Experience using emerging technologies such as high-throughput sequencing and droplet digital PCR.

  • Ability to design experiments, analyze data and interpret results independently and within a small, dynamic group of peers.

  • Critical and creative thinking.

Directions to apply 

Submit your resume to careers@beamtx.com

Any interested parties can contact directly Jason Gehrke at jgehrke@beamtx.com: “This is an excellent opportunity for students coming straight from a PhD program to get in at the scientist level. It's worth noting that we're also recruiting at the Master level as well”.