Beam Therapeutics

Scientist, New Opportunities

Beam seeks an experienced scientist to help us advance our New Opportunities programs, including discovering and validating the technical feasibility of novel genomic edits to disease-causing mutations with the ultimate goal of creating new therapeutic programs. The ideal candidate will be a self-motivated, technically competent scientist that is energized to join a small, fast-moving team.

Primary Responsibilities:

  • Critically evaluate and apply new base editor constructs to prospective disease targets.

  • Generate model cell lines for novel genetic targets and optimize on-target editing efficiencies.

  • Work with teams in specific therapeutic areas to translate editing to therapeutically-relevant cell types.

  • Design and implement cloning strategies to construct plasmids for the production of mRNA, protein, and recombinant

  • AAV reagents used in editing experiments.

  • Implement novel and established assays to assess large-scale genomic rearrangements and off-target effects of base editing technologies.

  • Design and execute DNA/RNA purification and quantification assays (qPCR, ddPCR and RNA-seq).

 

Qualifications:

  • PhD in biochemistry, molecular biology or related discipline.

  • Previous lentiviral production experience.

  • Experience culturing and transfecting common cancer cell lines such as HEK293T and U2OS. Experience culturing iPS cells is a plus.

  • Experience with molecular cloning techniques such as Gibson and USER assembly strongly preferred.

  • Experience using emerging technologies such as high-throughput sequencing and droplet digital PCR.

  • Ability to design experiments, analyze data and interpret results independently and within a small, dynamic group of peers.

  • Critical and creative thinking.

Directions to apply 

Submit your resume to careers@beamtx.com

Any interested parties can contact directly Jason Gehrke at jgehrke@beamtx.com: “This is an excellent opportunity for students coming straight from a PhD program to get in at the scientist level. It's worth noting that we're also recruiting at the Master level as well”.

2019 Kleiner Perkins Product & Design Fellows and Biotech Entrepreneurs

Applications for the KP Product Fellows Program and the KP Design Fellows Program are now open on http://fellows.kleinerperkins.com/


Here are some details on the program -

  • An exciting summer internship at one of our companies like Uber, Doordash, Robinhood and Shape Security for summer work experiences (for Design) and a full-time role (for Product)

  • Exclusive access to events and programming with our partners at Kleiner Perkins, CEO’s and executives across a variety of our portfolio companies

  • Fun social events like sailing to Angel Island, kayaking and paintball

  • An opportunity to connect with some of the brightest entrepreneurs across the country wanting to make an impact in San Francisco and Silicon Valley

  • 100K seed funding from Kleiner Perkins for Fellows who found their own companies. See blog post.

 

Here are a couple of quick videos to learn more about the summer:

KP Fellows Program

KP Fellows and Slack CEO Stewart Butterfield

Making an Impact


Applications for the 2019 KP Design Fellows Program and KP Product Fellows Program are open now and close January 31st, 2019 at 11:59PM on fellows.kleinerperkins.com.  The answer to most FAQ's can be found here. But if you have any other questions please feel free to reach out to Alicia from Kleiner Perkins at alicia@kleinerperkins.com.

FL62, Inc.

Company Overview

FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.

Position Summary

The (Sr.) Microbiologist will be primarily responsible for developing FL62’s biological delivery tools utilizing diverse microbes. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.

Key Responsibilities:

  • Design and execute experiments to validate the FL62 platform

  • Develop methods to repurpose microbe-host interactions

  • Work with senior leadership to develop and execute the scientific vision

  • Collaborate with CROs and other outside entities

  • Manage and mentor a team of junior scientists and RAs

Required Skills/Experience:

  • PhD and 2 yrs of postdoc or industrial experience in bioengineering, microbiology, or chemical engineering

  • Excellent understanding of host-microbe interactions, including secretion systems, secreted molecules, and surface protein interactions.

  • Experience with plant, fungal, or mammalian host-microbe interaction research

  • Experience growing and engineering diverse bacteria including E. coliPseudomonas,

    XanthomonasSalmonella, and Serratia.

  • Experience developing auxotrophic versions of the above species

  • Experience with inducible gene expression vectors

  • Experience producing bacteria in benchtop and laboratory-scale fermentation reactors

  • Experience with filtration and purification technologies, such as ultracentrifugation,

    tangential flow filtration, or irradiation.

  • Experience with novel assay development including reporter assays, molecular, and

    immune assays.

  • Excellent verbal and written communication skills

  • Strong organizational skills

  • Ability to work in a fast-paced and quickly changing environment

Desired Skills/Experience:

  • Experience engineering bacterial surface proteins or secreted effector proteins

  • Experience moving heterologous systems into model bacteria (e.g. E. coli)

  • Experience with extremophiles, cyanobacteria, or magnetotactic bacteria

  • Experience collecting human (e.g. fecal) and/or environmental (e.g. soil) bacterial

    isolates

  • Experience with studying microbe virulence factors

  • Experience working on bacterial energetics or flux analysis

If you are interested please reach out to David Kolesky directly: dkolesky@flagshippioneering.com.

FL62, Inc.

Company Overview

FL62, Inc. is a privately held, early-stage biotechnology company developing a novel platform to design, manipulate, and deliver microbes to solve major needs in human health and sustainability. VL62 was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, funds, and develops first-in-category life sciences companies. Since its launch in 2000, the firm has applied its hypothesis-driven innovation process to originate and foster over 75 scientific ventures, resulting in $19 billion in aggregate value and 500+ issued patents. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), Indigo, and Inari Agriculture. Since inception, Flagship has capitalized its growing portfolio with nearly $1 billion coming from $2.5 billion of aggregate investor capital committed.

Position Summary

The (Sr.) Microbial Engineer will be primarily responsible for the design, testing, and analysis of new delivery modalities. This individual will be a key member of FL62’s dynamic, expanding, and collaborative team that combines significant experience in microbe-host interactions, drug delivery, gene editing, tissue engineering, agriculture, and human health to unlock the potential of the company’s core technological platform.

Key Responsibilities:

  • Design and execute experiments to validate the FL62 platform

  • Develop methods to produce and characterize bacterial products

  • Work with senior leadership to develop and execute the scientific vision

  • Collaborate with CROs and other outside entities

  • Manage and mentor a team of junior scientists and research associates

  • Oversee molecular biology assay development.

Required Skills/Experience:

  • PhD and 2 yrs of postdoctoral or industrial experience in bioengineering, microbiology, or chemical engineering

  • Experience growing and engineering diverse bacteria including E. coliPseudomonas,XanthomonasSalmonella, and Serratia

  • Experience developing auxotrophic versions of the above species

  • Experience with modern large-scale knockout creation methods, such as CRISPR and

    lambda red recombineering

  • Experience working on bacterial energetics or flux analysis

  • Experience producing bacteria in benchtop and laboratory-scale fermentation reactors

  • Experience with filtration and purification technologies, such as ultracentrifugation,

    Tangential Flow Filtration, or irradiation.

  • Excellent verbal and written communication skills

  • Strong organizational skills

  • Ability to work in a fast-paced and quickly changing environment

Desired Skills/Experience:

  • Experience studying or modulating host-microbe interactions, including virulence, secretion systems, secreted toxins, and surface protein interactions.

  • Experience with plant, fungal, or mammalian host-microbe interaction research

  • Experience developing assays for novel synthetic biology applications

  • Experience with high throughput screening technologies

  • Experience with synthetic biology gene circuits

If you are interested please reach out to David Kolesky directly: dkolesky@flagshippioneering.com.

CRISPR Dx

Scientist I, Molecular Diagnostics Platform Innovation

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding scientist to work as part of a creative team dedicated to feature development and expansion of a leading molecular diagnostic technology platform. The successful candidate will contribute to driving the technology forward through innovations that will boost overall performance and robustness of the company’s CRISPR diagnostic platform.

The ideal candidate will have prior experience designing, developing, testing, implementing, and supporting molecular diagnostics assay workflows in a research or industrial environment. Experience working on diagnostics, in particular platform technologies, on cross-functional teams with success translating developments into product features is highly valued. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR- based platform for molecular diagnostics.

Duties and Responsibilities Include:

  •  Provides substantial, high-quality contributions to projects by working independently and leveraging the active support of others

  •  Independently identifies and utilizes relevant internal documentation and external publications to optimize procedures and processes

  •  Proactively and effectively interacts with counterparts across one or more departments to support achievement of project goals

  •  Creative problem solving and critical thinking skills for addressing technical issues during assay development

  •  Helps to design effective protocols to rapidly improve overall diagnostic performance

  •  Develops methods to translate platform improvements into solutions for IVD products that can

    be scaled for manufacturing

  •  Performs molecular laboratory methods including nucleic acid extraction, reverse transcription, quantitative PCR, and various other molecular diagnostic technologies.

Minimum Qualifications

  •  Master’s degree (+1 year relevant experience) or Bachelor’s degree (+3 years relevant experience) in molecular biology, biochemistry, bioengineering, biomedical engineering, chemical engineering, or a closely-related discipline is required; PhD preferred

  •  Experience with optimizing molecular diagnostics techniques

  •  Experience with data analysis, maintenance of data quality and technical troubleshooting

Experience

  •  Demonstrated ability to contribute effectively to cross-functional process development, improvement, and troubleshooting teams

  •  Strong written and oral communication skills with demonstrated track record of successful communication with internal teams and managers

  •  A track record of successfully completing assignments and meeting goals within aggressive timelines

  •  Knowledge of statistical process control charts and data interpretation

  •  Excellent organizational and planning skills

Please reach out to crisprdx@gmail.com with any questions.

CRISPR Dx

Research Technician, Molecular Diagnostics

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding technician to work as part of a dynamic team to develop and launch molecular diagnostic products. The successful candidate will execute studies, conduct data analysis, and document results. This role will interact with other groups and functionalities in the research and product development teams. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR-based platform for molecular diagnostics.

Responsibilities:

  • Contributes to experimental design, data analysis, critical thinking, and problem-solving to improve methods or procedures.

  • Conducts laboratory and study activities according to approved study protocols, Standard Operating Procedures (SOPs), and Work Instruction Documents (WIDs) to maintain the safety of self and colleagues and the integrity of the data collected.

  • Proficient at carrying out assignments with general guidance in planning, organizing and meeting deadlines.

  • Supports an atmosphere of inclusion and collective contribution to projects and procedures with team. Communicates regularly with supervisor to relay project progress, experiment results, and data analysis, and discuss challenges

  • Good documentation is essential to this position and includes recording all work, notebooks and other documentation for assigned projects/experiments

Skills and Experience:

  •  B.S or M.S. degree in Biology, Biochemistry, or related field or comparable industry experience

  •  0-2 years industry experience (IVD a plus)

  •  Knowledge and laboratory experience with molecular biology techniques. Strong analytical

    and quantitative skills.

  •  Excellent oral and written communication skills

  •  Capable of adjusting to dynamic working environment and changing priorities, while ensuring

    timely completion of assigned tasks

Please reach out to crisprdx@gmail.com with any questions.

CRISPR Dx

Scientist I, Molecular Diagnostics

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding scientist to work as part of a product development team to engineer and launch molecular diagnostic products across a range of impactful healthcare applications. The successful candidate will contribute to new product initiatives through requirement definition, prototype design, reaction optimization, verification, validation, and assay troubleshooting.

The ideal candidate will have prior experience designing, developing, testing, implementing, and supporting molecular diagnostics assay workflows using a requirement-driven approach – equivalent academic experience is highly valued and will qualify. Experience working on cross-functional teams to apply scientific methods and product/process design principles in establishing and improving quality control and manufacturing processes is a plus. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR-based platform for molecular diagnostics.

Duties and Responsibilities Include:

  •  Provides substantial, high-quality contributions to projects by working independently and leveraging the active support of others.

  •  Independently identifies and utilizes relevant internal documentation and external publications to optimize procedures and processes.

  •  Creative problem solving and critical thinking skills for addressing technical issues during assay development

  •  Proactively and effectively interacts with counterparts across one or more departments to support achievement of project goals.

  •  Helps to design guard-banding parameters, verification tests and validation experiments

  •  Performs primary data analysis of results, and provides substantial contributions to internal

    technical reports and design documentation

  •  Writes and reviews experimental protocols and Standard Operating Procedures, incorporating

    input from other team members efficiently and effectively

  •  Performs molecular laboratory methods including nucleic acid extraction, reverse transcription,

    quantitative PCR, and various other molecular diagnostic technologies.

  •  Participates in cross-functional process development and improvement teams focused on

    improving efficiency, throughput, cost, and quality

Minimum Qualifications

  •  Master’s degree (+1 year relevant experience) or Bachelor’s degree (+3 years relevant experience) in molecular biology, biochemistry, bioengineering, biomedical engineering, chemical engineering, or a closely-related discipline is required; PhD preferred.

  •  Experience with data analysis, maintenance of data quality and technical troubleshooting.

Experience

  •  Demonstrated ability to contribute effectively to cross-functional process development, improvement, and troubleshooting teams.

  •  Strong written and oral communication skills with demonstrated track record of successful communication with internal teams and managers.

  •  A track record of successfully completing assignments and meeting goals within aggressive timelines.

  •  Knowledge of statistical process control charts and data interpretation.

  •  Excellent organizational and planning skills.

Please reach out to crisprdx@gmail.com with any questions.

CRISPR Dx

Director of Assay Development, Molecular Diagnostics

An exciting new diagnostic company based on a next-generation CRISPR and synthetic biology technology platform is seeking an outstanding Director of Assay Development to lead product development teams to engineer and launch molecular diagnostic products. The successful candidate will be responsible for strategic direction of new products, planning and execution of research and development activities. In addition, the successful candidate will help drive the innovation of the platform and translate improvements into new products. This role provides strategic and technical leadership in defining and achieving product development objectives while ensuring compliance with health authority requirements. The Director of Assay Development is also responsible for partnering with life cycle teams and internal as well as external business partners to drive product development. This role will drive continuous improvement within product development processes and manage resources to achieve business results within budget. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through a highly innovative CRISPR-based platform for molecular diagnostics.

Duties and Responsibilities include:

  •  New Product Planning – Interacts with Marketing to set product specifications, timing, resources and provide technical expertise.

  •  Oversees critical reagent development, validation, and transfer to Operations.

  •  Project Management – Oversees the management of cross-functional teams in the development

    and commercialization of reagent applications and new product development.

  •  New Product Development – Conducts feasibility studies. Develops reagents within design

    control process and oversees validations. Oversees research and development of new products,

    as well as the transfer of products to Operations.

  •  Directs analytical studies for Marketing and FDA approval and ensures GMP, ISO and IVDD

    compliant documentation.

  •  Addresses strategic and technical issues; prepares departmental budgets; monitors department

    spending.

  •  Directs departmental staff including: interviewing and hiring staff, providing performance

    feedback and reviews, counseling, developing, rewarding, completing progressive disciplinary

    and terminating.

  •  Monitors work to ensure quality, and continuously promote First Time Quality.

  •  Responsible for employee development including leaders and all level of scientists in the

    organization. Responsibilities also include developing workforce planning models and developing skills sets within team to meet future technology requirements

Minimum Qualifications:

M.S. in a Life Sciences Discipline (Biochemistry/Immunology/Pathology/Molecular Biology). PhD preferred, or equivalent experience.

Experience:

  •  With MS in Life Sciences: Eight (8) years combined academic and industry with direct experience in an IVD company.

  •  With PhD in Life Sciences: Six (6) years combined academic and industry with direct experience in an IVD company.

  •  4 years of management experience.

  •  Experience working with Marketing, Quality Assurance and Operations.

  •  Demonstrated record of accomplishments (e.g., publications in scientific journals, issued US

    patents).

Preferred Qualification:

8+ years of management experience

Knowledge, Skills, and Abilities:

  • Strong background in assay development, including immunoassay and immunohistochemistry or in situ hybridization and nucleic acid detection.

  • Demonstrated knowledge of cell biology, pathology, histology, molecular biology, chemistry, or biochemistry. Experience with immunohistochemistry preferred. Must demonstrate technical aptitude to learn different scientific applications quickly.

  • Experienced in IVD product development and FDA submissions.

  • Excellent leadership and communication skills, creative problem solver especially in technical areas.

  • Familiarity with the various regulatory requirements (GMP, ISO and IVDD).

  • Must work well with cross functional teams.

Please reach out to crisprdx@gmail.com with any questions.

Regeneron Pharmaceuticals

Job Title: Immuno-oncology Scientist

Location: Tarrytown, NY (near New York City)

Requisition Number: 14586BR

 

Company Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Visit us at www.regeneron.com .

Summary

The successful candidate will directly contribute to the development of novel antibody therapeutics to treat a variety of malignancies in patients. This candidate will join a dynamic, high-profile, and multidisciplinary team that studies an array of anti-tumor immunotherapies including checkpoint inhibitors.


The scientist will be responsible for validating our expanding portfolio of antibodies that have been engineered to engage a variety of immune effector pathways, including co-stimulatory signaling. Specifically, this candidate will develop novel animal models to conduct complex in vivo and ex vivo murine tumor studies to test rational combinations of cancer therapeutics with the goal of advancing leads to the clinic.


The qualified individual will have a strong background in one or more areas of tumor biology, immunology, oncology, and/or immuno-oncology.


Ideal applicants will possess excellent interpersonal and communication skills, as this candidate will be expected to work productively in a collaborative, cross-functional team environment. 


Further, critical problem-solving abilities and a commitment to scientific excellence are desired.

Responsibilities
• Design, plan, and independently perform complex anti-tumor efficacy studies in mice including: cell culture, dosing (IV, SC, IP), and measuring tumors, as well as the dissection of immune organs for subsequent ex vivo analysis.
• Develop novel murine models to investigate combinatorial immuno-therapeutic strategies
• Design flow cytometry (FACS) panels and perform FACS analysis on human and murine cells, tumors, and tissues
• Synthesize results across experiments and programs in PowerPoint presentations and present to colleagues and senior management, including clinical and regulatory teams.
• Responsible for authoring documents to be published in regulatory filings, patent applications, external conference posters, and journal articles.
• Work successfully in cross-functional teams by contributing data and ideas
• This Scientist position comes with the potential to manage Research Associates

Requirements

This position requires a minimum of a Ph.D, and experience in the below:
• Skilled in the design of complex studies to interrogate in vivo efficacy of novel therapies.
• Ability to independently perform in vivo efficacy studies in both immunocompetent and immunocompromised mice (tumor implantation, monitoring tumor growth by caliper or bioluminescence (IVIS), and monitoring survival)
• Skilled in ex vivo and in vitro techniques, including the culture of human and mouse cells and the analysis of serum cytokine levels
• Skilled in development and design of FACS antibody panels and analysis of FACS data
• Demonstrated interpersonal and written/oral communication skills


This position will require the individual to pass a physical before beginning employment.


This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry.

Apply today https://careers.regeneron.com/job/REGEA0026307066/Immuno-oncology-Scientist  and learn more about Regeneron’s unwavering commitment to combining good science & good business. 

Qiming Venture Partners

Qiming Venture Partners USA, The Mohamed Chaoui Venture Fellowship 2019

www.qimingvcusa.com

The Mohamed Chaoui Venture Fellowship: A fellowship for those of you seeking the challenge of a career in venture capital.

A former colleague [of a Qiming US partner] and a true friend to the firm, Mohamed Chaoui, recently passed away following a battle with lung cancer. He has inspired us to create a fellowship to help develop MBA, MD, Ph.D., PharmD or other advanced degree candidates with a unique Qiming US experience.

Mohamed’s multi-company and multi-national career included banking, M&A, corporate finance, business development, general management overseeing biopharma affiliates, and for UCB, was instrumental in catalyzing the growth of their China operations. Mohamed was quick to understand early in his career that biotech and biomedical firms, many of which were venture-backed, could provide the means to discover, develop and commercialize transformational products. Mohamed was full of life. He had a daring spirit, boundless courage, abundant creativity, passion for pursuing innovation, and most importantly, a clear sense of purpose to patients. For any of us that had the chance to work with him, his impact will never fade.

For these reasons, we have created a fellowship to honor our colleague and friend. We commit to an experience that will provide a glimpse at how we work, help us answer important questions, gain insight into young company creation, work side-by-side with very talented people and have a memorable experience.

Qualifications
• Ph.D., M.D., MBA and/or PharmD degree with focus in life sciences required
• Experience in a business setting beneficial (e.g. consulting, BD, finance)
• Familiarity with China ecosystem and spoken language beneficial but not required
• Self-starter, ability to identify creative solutions independently
• Strong communication and presentation skills
• Passion for healthcare innovation
• Fast learner with ability to get up to speed in technical areas outside core experience
• Proficiency in Excel and PowerPoint

Responsibilities
• Conduct due diligence on potential investments independently and as part of core Qiming team
• Present at internal investment committee as contributor to investment decisions
• Strategic analysis of opportunity landscape incl. regulatory, scientific, clinical and IP
• Evaluation of China opportunities for current and potential investment companies
• Strategic and operational support to portfolio companies, as required
• Source potential investment opportunities

Application process

The application is simple. Send us a one or two paragraph note telling us why you are interested in the role, and what special abilities you’ll bring that can help us develop throughout a 3-4 month period with Qiming, in one of our 3 locations (Cambridge, Bay Area or Seattle). Attach your CV, and tell us what timing is optimal in 2019. Please send your application to: contact_UShealthcare@qimingvc.com.

AJU IB

Overview

AJU IB is a leading South Korean venture capital firm with an office in Boston that is dedicated to investing in breakthrough biotechnology and life science companies. Our mission is to build and fund transformational innovations that have the potential to make a meaningful difference to patient outcomes and quality of life.

Position & Who Should Apply

This is an entry-level position for full time employment in Boston. The ideal candidate for this role is someone who possesses an MD or PhD in a life sciences field and has a demonstrated interest and deep domain knowledge of the biotechnology and pharmaceutical industries.

Responsibilities

• Member of core team conducting due diligence and deal sourcing activities

• Evaluate scientific evidence, clinical paradigms, IP and commercial landscapes

• Contribute to internal investment committee review process to arrive at financing decisions

• Screen business plans and investment proposals

• Work on operational and strategic issues for current and potential portfolio companies

• Scientific and clinical data analysis

• Generate new investment themes through primary research and source potential new investment opportunities

Qualifications

• PhD and/or MD degree in life sciences required—strong translational research focus is a plus

• Additional business experience a plus (e.g. finance, consulting, business development, technology licensing, patent law, operations, etc.)

• Quick learner that can get up to speed in technical areas outside core expertise

• Strong passion for medical innovation and entrepreneurial drive

• Strong presentation and communication skills

• Self-starter; ability to run with things without much oversight

• Highly analytical, open-minded, deep thinker

• Team player with low ego

Applying

If interested in learning more, please send resume/CV to hugo.beekman@ajuib.com.


64-x

Company Website: https://www.64-x.com/

We founded 64-x with the mission to engineer microbes that solve longstanding problems in biomanufacturing, bioremediation & health. We’re looking for creative thinkers that are passionate about making this vision a reality. We are a team of founders from Harvard, Yale, and the Wyss Institute of Biologically Inspired Engineering, backed by leading venture funds such as Y Combinator, First Round Capital and SV Angel. We have many positions open, from strain engineering to business development. If you want to be a part of an energetic and collaborative team with an impactful mission, join us. We're really excited to meet you!

Positions Available:

1. Scientist - Microorganism Engineering: We’re looking for a highly motivated and talented scientist to lead our microorganism engineering team. This scientist will lead the development of a novel class of bacterial organism “chassis” with the potential to address longstanding problems in bioremediation, biomanufacturing and health. 

2. Scientist - Strain Engineering: We’re looking for the best scientists to join our strain engineering team. These scientists will work closely with our microorganism engineering team, and use novel bacterial chassis to both generate and characterize new strains with targeted characteristics. 

**If you don't see a perfect match or just want to learn more, send us a message at careers@64-x.com!

Link to job postings:

https://angel.co/64minusx/jobs 

Bionest Partners

Oncology-Focused Associate Consultant

Bionest Partners is a boutique strategy consulting firm focused exclusively on the life sciences. We work with our clients to help them answer key issues that arise during the development and commercialization of their products and support them in addressing the most critical issues in today’s market – securing new sources of growth, enhancing competitive positioning, and optimizing market efforts.

We work on a broad range of projects such as:

  • Corporate development strategy, including franchise and portfolio strategy

  • Personalized medicine development strategy

  • Asset valuation

  • Clinical and commercial strategy for new products

  • Market access strategy and operational planning

Our clients include large and specialty biotech / pharma, medical products, diagnostics, and service-based companies. We bring particular expertise in working with early-stage companies and small-cap and middle-market situations.

We are seeking to add one Oncology-Focused Associate Consultant to our team. 

Responsibilities include:

  • Coordination and execution of market research (primary and secondary)

  • Market and competitive analyses

  • Synthesis of findings

  • Development of insights

  • Evaluation of options and development of recommendations

  • Client presentations

The successful candidate will have:

  • Oncology-focused Ph.D. from a top-tier program with 0-2 years of consulting experience

  • Strong experience in oncology research (translational research experience is a plus)

  • Basic knowledge of oncology market, e.g., key trends and dynamics, challenges facing oncology drug development and commercialization etc.

  • Strong communication skills, both written and verbal

  • Proficiency in the use of Microsoft Office, particularly PowerPoint and Excel

  • Motivated and self-initiating

  • A learning mindset with strong time management skills and the ability to deliver high quality outputs under time-pressured deadlines

  • Excellent attention to detail

  • A positive attitude and the drive and desire to progress in the organization

Please apply with resume and cover letter at recruitnewyork@bionest.com

GENESIS

Genesis, an innovative and ambitious social start-up, is looking for interns with a real passion to bring social change.  If you are looking for a challenging internship in the entrepreneurial world that combines educational programming, new technologies, and improves underprivileged societies, we want you!

 

Who are we?

Genesis is an early stage Israeli NGO.  Our main goal is to prevent genetic diseases and birth defects in the Bedouin society in Israel and provide a healthy beginning to all children.  Please visit our website: www.genesismed.org

 

Internship Opportunity: we offer a number of positions for interns who wish to gain experience in the fields of public and global health, medical genetics, business development and market research, marketing and/or technological solutions for preventive medicine.

           

Potential Areas of Responsibility:

  • Writing content–Conducting literature reviews on the common genetic diseases in the Bedouin community. End goal is both publishing scientific papers as well as establishing a web page that can be easily understood by all.

  • Global market research– Researching and mapping similar societies and solutions, to better understand the global problem. This will include gathering and analyzing external information about relevant issues, program design and operating environment, to allow us to make improved decisions on how to achieve our goals.

  • Cost-analysis reports–Writing cost-analysis reports on the common genetic diseases in the Bedouin community, based on the WHO guidelines.

  • Cost reduction analysis –Assisting in determining which costs our organization can cut without impacting its ability to deliver on its mission. Analyzing our administrative and operational expenses, workflows, and supply chain.

Some other ways you can make an impact:

  • Evaluation and Key Performance Indicators

  • Pitch development (business proposal/grant writing)

  • Research grants & proposals

  • Varied funding model

  • Management reporting systems/Databases Organizational learning and knowledge management

  • HR policy manual

  • Social media and Website

Qualifications:

  • Excellent written and verbal communication and time management skills.

  • Interest in public health issues.

  • Self-starter - ability to meet deadlines and work independently.

  • Strong analytical and quantitative abilities.

  • Excellent written and verbal communication  as well as time management skills.

  • Extremely attentive to detail, accurate and thorough.

  • Advantage (but not necessary) - fluent Arabic/Hebrew speakers.

  • Experience in marketing and/or business development for startup NGOs.

  • Experience in developing business models for public health organizations.

  • Work experience with WHO, Gates Foundation, The Clinton Foundation, other aid foundations and consulting firms that relate to these and similar organizations.

 

Internship Details:

o   This will likely be an unpaid internship.  However, several Harvard programs provide funding and credit opportunities and we can assist in any way to support your application process.

o   For example, through HBS you can get class credit for doing an Independent Project, get summer internship funding through the Rock Summer Fellows, or the HBS Social Enterprise Initiative. 

o   Because the organization staff is located in Israel, weekly communications will be conducted via Skype. We will provide training, orientation, and mentorship.

o   Weekly schedule is flexible and work is done remotely; thus, we are looking for students who enjoy taking initiative and remaining self-motivated.

GSK

Post- Doctoral Investigator - Molecular Virology

Your Responsibilities
The goal of this post-doctoral project (funded for three years) is to develop a system for the rapid identification and testing of new vaccine candidates in response to an outbreak by an emerging pathogen.  This specific project is just one part of a wider effort within GSK Vaccines to further advance our nucleic acid-based vaccine platform called SAM, which is an engineered Self-Amplifying mRNA replicon designed and formulated for vaccine purposes.  SAM molecules have been shown to trigger a broad and robust immune responses to a number of encoded antigens in preclinical animal models.  The post-doctoral candidate will form part of a team of scientists from both GSK and external collaborators to advance this platform using state-of-the-art computational biology, genomics, and high-throughput workflows.

To be successful in the role, this person must:

-have the ability to understand, interpret, and communicate complex scientific data
-be comfortable conversing with opinion leaders regarding highly technical information
-be a self-starter able to handle multiple projects concurrently
-possess a good balance of creative, analytical, and communication skills
-be productive and successful in an intense work environment and he/she must be a Team Player

Why You?

Basic qualifications: 
-Ph.D. degree  and/or a M.D./Ph.D. in Virology, Molecular Virology, or Molecular Biology related disciplines
-Extensive expertise of cell biology and molecular biology techniques including cell-based assay development and screening, molecular cloning, and virology
-Hands-on experience in imaging technologies, including fluorescence and confocal microscopy
-Basic skills in statistical analysis
-Strong track-record of scientific publications in peer-reviewed journals, including at least one as a first author
-Fluency in English, spoken and written

Preferred qualifications: 
-Experience working with RNA viruses and manipulating viral systems
-Experience with high-throughput cell-based assay development and screening
-Experience with Next-generation sequencing technologies
-Excellent communication and presentation skills and the ability to collaborate in multiple project work streams

Why GSK?
In September 2015, GSK established a new global centre for vaccines research and development (R&D) in Rockville, Maryland.  The site is one of three global vaccines R&D centres for GSK, complementing the company’s existing global R&D centres in Rixensart, Belgium and in Siena, Italy.
The new US vaccines R&D centre will expand GSK’s efforts to discover and develop novel vaccines across a range of pressing public health threats, including those relevant to the US. It will consolidate vaccines R&D activities currently conducted at other GSK sites including in Philadelphia, PA and Cambridge, MA, into one centralised location. Key late stage development programmes, as well as vaccine discovery and new platform technology development will be led from Rockville.

Our Vaccines business has a broad portfolio and innovative pipeline of vaccines to protect people of all ages. We deliver over two million vaccine doses per day to people living in over 160 countries. The vaccines in our portfolio have been helping to protect people from serious disease for well over 100 years, with our Marietta (US) site dedicated to smallpox vaccine production since 1882.  Today, our vaccines continue to tackle some of the world’s most devastating diseases, including pneumococcal disease, meningitis, hepatitis, rotavirus, whooping cough and influenza. Our Vaccines business has a portfolio of more than 40 vaccines for every stage of life, helping to protect people against 22 diseases. We have a pipeline of 14 candidate vaccines in development. One third of our vaccines in development target diseases particularly prevalent in the developing world, including all three WHO infectious disease priorities: HIV, malaria and TB. Our other vaccines in development include vaccines for the treatment of COPD and prevention of Respiratory Syncytial Virus (RSV). In October 2017, our shingles vaccine, Shingrix, received regulatory approval in Canada and the US.

GSK has a 150-year legacy of helping to transform the health, lives and futures of millions of people around the world.  We’re a science-led healthcare company with more than 100,000 people working in 115 countries. Each year we produce around 4 billion packs of medicine, nearly 900 million doses of vaccine and more than 18 billion packs of consumer healthcare products.  Our focus of helping people do more, feel better and live longer is at the center of all that we aim to do. 

At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.

Contact information: 
You may apply for this position online by clicking here.

Kaleido

Description

Biology Co-op

Apply:  https://www.kaleido.com/join-us/

 

The microbiome produces hundreds of bioactive chemistries that affect our biology. To date, the vast majority of research in medicine and nutrition has focused on the interaction between chemistries and human cells – overlooking the essential role of our microbiome. Kaleido is pioneering a large category of novel chemistries that can control the entire metabolic profile of the microbiome, offering new ways to approach the treatment of disease and management of health.


Be part of an exciting team that is dedicated to revolutionizing human health. Kaleido Co-Ops will:

  • Work on a personal project that is important to Kaleido’s mission.

  • Be supported by a mentor who will provide a unique perspective on projects and careers.

  • Have the opportunity to participate in the pioneering of novel chemistries that control the 

     microbiome.

 

This position will work within our Biology Group.

 

Overview:

The proper function and structure of the human microbiome is increasingly understood to be a major driver of human health.  The unique biology of the microbiome presents an extraordinary opportunity to develop life-saving therapeutics that interact specifically and selectively with the microbiome to improve human health outcomes.  Kaleido’s mission is to build and deploy the world’s first and premier drug discovery engine targeted specifically at the microbiome.  To that end, co-ops will join Kaleido’s Biology Department to pursue the goal of understanding how novel drug candidates impact the microbiome.  The role will involve exploration of carbohydrate utilization capabilities of various microbiomes, and contributions to discovery project teams in the areas of in-born metabolic disorders, bacterial infections, and inflammation. 

 

Qualifications:

  • Pursuing an undergraduate or graduate degree in molecular biology, biochemistry or microbiology

  • Laboratory experience in an academic lab or a biotechnology company (internship/co-op, minimum 6 months)

  • Self-motivated, curious and excited to work in a high energy environment

  • Previous co-op or intern experience preferred.

  • Able to work independently

 

 

Work Schedule and Salary Information:

January-June Rotation  

$18-22 per hour depending upon experience, 40 hours per week.

 

Kaleido is located at 65 Hayden Ave, Lexington, MA (transportation from Alewife station available).  For more information, go to www.kaleido.com

Sanofi

Position Title: Postdoctoral Fellowship: Lipidomics

Location: Waltham, MA

A Post Doctoral Scientist is needed to participate in development and application of a cutting edge lipidomics platform for biochemical fingerprinting of biological samples and identification of the disease biomarkers. It will support implementation of a novel approach to drug discovery and development based on translational biomarkers by identification of lipids associated with progression of disease. The work will include testing of innovative approaches for designing longitudinal studies, selection of appropriate controls and normalization approaches for identification of disease progression lipid biomarkers.

Qualifications:

  • PhD from an accredited university in Analytical Chemistry or related field

  • Experience with LC-MS, High resolution mass spectrometry and analysis of lipids

  • Must have US work authorization



Please click here for more information.

Sanofi

Position Title: Postdoctoral Fellowship: Bioprocess Analytics

Location: Framingham, MA

We are looking for candidates for an exciting post doc position to join our Bioprocess analytics team. The ideal candidate will join a dynamic and PAT motivated team and will serve as a key subject matter expert supporting bioprocess process development, data analytics and statistics process control

We are looking for candidates for an exciting post doc position to join our Bioprocess analytics team. The ideal candidate will join a dynamic and PAT motivated team and will serve as a key subject matter expert supporting bioprocess process development, data analytics and statistics process control activities using vibrational spectroscopic technologies.  

Major Job responsibilities:

  • Invisible to visible spectral characterizations of CQAs using pattern recognition, artificial intelligence, machine learning and established pleiotropic network of biomolecules.

  • Analyze large data sets which include real-time bioprocess data and offline analytical data sets.

  • Characterizations and interpretations of cell culture’s critical quality attributes (CQAs) and parameters using UV, Raman, FTIR, Imaging, florescence and FBRM spectroscopy. 

  • Develop Chemometrics data analysis concepts and modeling in support of batch and continuous manufacturing.

  • Develop a Chemometrics predictive modeling platform, exploratory data analysis, Chemometrics model development, validation and model maintenance.

Basic Qualifications:

  • PhD from an accredited university in Process Spectroscopy, Chemometrics, chemical engineering or process engineering

  • Expertise in developing, interpreting, implementing and managing vibrational or other spectroscopic techniques such as FTIR, NIR, Raman, Imaging, florescence and FBRM or related techniques with a strong publication record

  • Strong expertise on Chemometrics data modeling combined with invisible to visible modeling concept using Bioprocess data

  • Expertise on machine learning, neural networks, clustering, pattern recognition, probability, supervised and unsupervised data modeling

  • Outstanding experience on upstream, downstream bioprocess and cell culture data mining

  • Expertise in analyzing mass spectrometric, chromatographic, thermal and genomic data analysis using machine learning and support vector machine

  • Advance skills with R, C++, and MATLAB/Simulink, and Neuron

  • Must have US work authorization

Preferred Qualifications:

  • PAT implementations in continuous manufacturing environment is plus

Please click here for more information.

Novartis

Position Title: Investigator, Oncology Bioinformatics

Location: Cambridge, MA

Job Description 

Novartis Institutes for BioMedical Research, Inc. (NIBR) is seeking a computational biologist / bioinformatics analyst to join the Novartis Oncology Bioinformatics Team. Oncology Bioinformatics provides computational biology expertise to the department, from target ID through clinical development, for both targeted and immune therapies. We work at the cutting edge of science to solve important challenges in biomedical research, making use of both publicly available and internally generated unique and expansive preclinical and clinical datasets. The successful candidate will be highly motivated, creative, and an effective collaborator.
Responsibilities will include:
• Working closely with wet- and dry-lab collaborators to analyze and interpret high-dimensional data such as pooled library NGS screening, single cell RNAseq, and proteomics.
• Supporting translational genomics, model characterization, and data mining efforts to solve unmet medical needs.
• Implementing and developing state-of-the-art computational methods and data mining strategies to address key challenges in oncology drug discovery (e.g. drug resistance, difficult-to-drug targets, harnessing anti-tumor immunity).
• Formulating testable hypotheses, and collaborating in the design of rigorous experiments. 

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

• Ph.D. in computational biology, statistics, computer science, or a related field
• Familiar with fundamental concepts in molecular biology, statistics, and bioinformatics
• Fluency in one or more programming languages with bioinformatics applications (e.g. Python or R)
• Experience with statistical methods for mining ‘omics data (genomics, epigenetics, proteomics) and/or NGS data strongly preferred
• Knowledge of cancer genomics, immunology / immune-oncology, clinical and translational science preferred
• Experience with current analysis methods for single-cell RNAseq, clinical biomarkers, and patient stratification preferred

Please click here for more information.

Novartis

Position Title: Oncology Data Scientist

Location: Cambridge, MA

Job Description 

Novartis Institutes for BioMedical Research, Inc. (NIBR) is seeking a computational biologist / bioinformatics analyst to join the Novartis Oncology Bioinformatics Team. Oncology Bioinformatics provides computational biology expertise to the department, from target ID through clinical development, for both targeted and immune therapies. We work at the cutting edge of science to solve important challenges in biomedical research, making use of both publicly available and internally generated unique and expansive preclinical and clinical datasets. The successful candidate will be highly motivated, creative, and an effective collaborator.
Responsibilities will include:
• Pioneering and implementing artificial intelligence solution to biological problems
• Working closely with wet- and dry-lab collaborators to analyze and interpret biomedical imaging data.
• Supporting translational biology, model characterization, and data mining efforts to solve unmet medical needs.
• Implementing and developing state-of-the-art computational methods and data mining strategies to address key challenges in oncology drug discovery (e.g. drug resistance, difficult-to-drug targets, harnessing anti-tumor immunity).
• Formulating testable hypotheses, and collaborating in the design of rigorous experiments. 

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

• Ph.D. in computational biology, statistics, computer science, biomedical informatics, biological engineering, or a related field
• Experience with current analysis methods for AI, particularly deep learning. Experience with convolutional neural networks and frameworks such as Keras or Tensorflow is a plus.
• Experience with computer vision and image analysis software such as OpenCV
• Experience analyzing medical imaging data. Experience with digital pathology (H&E, IHC) and/or radiology preferred
• Familiar with fundamental concepts in molecular biology, statistics, and bioinformatics
• Fluency in one or more programming languages. Python is a plus.
• Experience with statistical methods for mining ‘omics data (genomics, epigenetics, proteomics) and/or NGS data preferred
• Knowledge of cancer genomics, immunology / immune-oncology, clinical and translational science preferred

Please click here for more information.