Evercore ISI

Job description:

NYC-based equity research Associate position covering pharmaceuticals and biotech on the top ranked team.  Unlike other equity research roles (which are very specific to one sub-sector), this role spans a very broad set of responsibility – ranging from specialty pharma to generics to biotech.  This in turn means lots of room to learn a very diverse skillset as well as lots of exposure to top investors.  Past members on the team have moved on to extremely coveted roles.

What to expect:

We are a small team and work very closely together.  There is a high amount of exposure with investors and executive teams of spec pharma, biotech, pharma companies.  As a result, there is a clear expectation that the candidate has a good attitude, is self-driven, very intellectually curious and can figure things out very quickly. 

Requirements:

-       Strong science background (don’t necessarily need a PhD – BS/MS in chemistry/bio is good) … also open to MD or PhDs if someone is exceptional

-       Super excited to learn

-       Comfortable working investment banking hours (including late nights and weekends)

-       Basic understanding of financial modeling (<although we’re flexible on this)

Skill set you will develop:

-       Ramping up on a new therapeutic area instantly

-       Dissecting clinical data & stats

-       Patent law

-       Public speaking & professional relationships

-       Financial modeling

Compensation:  

very competitive

Bristol-Myers Squibb

What:           

The Bristol-Myers Squibb 2018 Golden Ticket Program (“Program”) is a competition for the award of two Golden Tickets. 

A Golden Ticket is one year of underwritten lab bench space at LabCentral (Cambridge, MA), including all resident benefits, for a promising life science start-up.  The Program will award a total of two Golden Tickets in 2018 to the one or two companies that best meet the judging criteria of the Program including that they are engaged in therapeutic research in the fields of Oncology, Immunology, Cardiovascular, or Fibrosis, and/or are companies pursuing research in novel target identification, drug delivery, discovery technology platforms, or translational R&D.

LabCentral provides fully equipped, permitted, and supported lab space for biomedical research, plus programming and unmatched networking opportunities to help start-ups advance their science and build their companies. Visit: http://labcentral.org/facilities-services/ to learn more.

When:          

Applications for the Program are being accepted through July 6, 2018.

To apply:     

Click here

Biogen

Postdoctoral Scientist - Parkinson's Disease

US-MA-Cambridge

Summary

The Neuromuscular and Movement Disorders Department at Biogen is seeking a highly motivated, creative and independent Postdoctoral Research Fellow to join Dr. Andreas Weihofen and Dr. Warren Hirst’s lab which is responsible for bringing new targets and therapeutic strategies from discovery to development for Parkinson’s Disease and other movement disorders.

Job Description

Alpha-synuclein plays a causative role in the pathogenesis of Parkinson’s Disease. Disruption of numerous intracellular trafficking steps induced by changes in alpha-synuclein homeostasis, distribution and interaction with specific membranes, is hypothesized to drive alpha-synuclein pathophysiology. Using transcriptional profiling studies in cell-based alpha-synuclein models we have identified a discrete set of genes that are differentially expressed before alpha-synuclein induced neurotoxicity is observed. These genes can be linked to pathways related to dysfunction in the early secretory pathway, fatty acid and phospholipid biosynthesis. The aim of the postdoc is to address following key questions: 
-How do genes identified in transcriptional profiling studies: lipidome and dyshomeostasis of alpha-synuclein membrane binding contribute to alpha-synuclein cell toxicity, specifically related to organelle trafficking dysfunction and to α-syn secretion in cell-based alpha-synuclein models? 
-Can the pathophysiology of novel alpha-synuclein propagation mouse models be corrected by genes & molecules modulating lipidome? 
The successful candidate will be responsible for applying a wide range of cellular, biochemical and molecular biology techniques to address these key questions. These will include advanced cell-based assays, with primary and iPSC-derived neurons, CRISPR, lipidomic analysis and in vivo studies in transgenic and other Parkinson’s disease mouse models.

Qualifications

The successful candidate must possess significant understanding of basic neurobiology of neurodegenerative diseases and mechanisms of neurodegeneration and a strong desire to learn and perform neurology research in an industry setting. Prior knowledge in alpha-synuclein or lipid biology is a plus. 
•Experience in culturing and manipulating primary or iPSC derived neurons and basic knowledge in handling mice is desired.
•Strong communication & interpersonal skills and the ability to work effectively in a highly collaborative research environment will be required.
•The successful candidate should have a proven track record of independent research, demonstrated by impactful scientific publications.

Education

Ph.D. degree in the areas of Neurobiology, Cell Biology or similar relevant field.

To apply, please contact Evgeny Shlevkov directly at evgeny.shlevkov@biogen.com.

Indee Labs

Indee Labs develops hardware for gene delivery. Our focus is on gene-modified cell therapy development and manufacturing. Gene-modified cell therapies are the most effective platform for patients with late-stage and advanced disease. Nobody knows how to reliably manufacture gene-modified cell therapies at scale.

 

We are seeking a bioengineer to join the team full time to accelerate the development of our microfluidic gene delivery platform. Indee Labs is based at Bonneville Labs in Berkeley, CA with satellite offices in North Sydney, NSW and Adelaide, SA in Australia. The team is backed by Y Combinator, Founders Fund, Main Sequence Ventures and Social+Capital among others.

Requirements:

● Experience in primary human cell culture

● Experience in mammalian cell engineering

● Experience with immunological lab techniques and methods

● Work Authorization in the United States

Preferred Skills:

● Industry experience

● Interest in or experience with microfluidics

● Primary immune cell transfection or phenotype analysis

● Experience designing vectors for cell transfection

● Demonstrated research track record

● Ability to work independently and lead others

● Ability to manage a small lab

● Background or strong interest in entrepreneurship

● Located in or willing to relocate to the Bay Area

 

Please send your resume and cover letter to careers@indeelabs.com.

Boxer Capital

Boxer Capital, under the Tavistock Group, is seeking an Investment Analyst Intern to join our biotechnology investment team in San Diego, California.

 

Boxer Capital is a healthcare-focused investment firm whose mission is to identify biotechnology companies that aim to drastically improve medicine.  Our goal is to recognize innovation in biotechnology and aggressively pursue investment opportunities. This position is ideal for someone who is passionate in understanding novel therapies targeting unmet medical needs, and who desires to learn more about investing in biotechnology.

Responsibilities of the Investment Analyst Intern will include:

  • Summarizing key information from medical journals spanning a broad range of topics

  • Assisting with due diligence on potential investment opportunities

  • Developing and maintaining accurate and detailed project documentation including timelines, action items and agendas

Qualifications include:

  • PhD, MD, PharmD or Master’s candidates in the sciences

  • Healthcare exposure, either academically or job-related

  • Excellent communication, problem solving, and analytical skills

  • Detail-oriented, mature, conscientious, and trustworthy

  • Highly proficient in the use of Microsoft Office Suite programs particularly Excel

  • Ability to work on multiple projects at one time and maintain tight and aggressive deadlines

  • The ability to work both independently and in teams

  • Desire to learn the biotechnology hedge fund industry

About Tavistock Group:

Tavistock Group is an international private investment organization founded by Joe Lewis more than 35 years ago. Our reputation is built on a simple philosophy – we strive for excellence in everything we do.  Entrepreneurial and progressive, we value long-term relationships and seek investment opportunities around the globe, which will benefit from our capital, experience, flexibility and broad base of resources.

To Apply:

Please email your resume along with the answer to the following question in one file to resumeboxcap@tavistock.com with the subject line: “Investment Analyst Intern Position”

  1. How do you approach mastering a new topic?

Cyngal Therapeutics

Job Description: Scientist – Immunology

The Company

Cygnal Therapeutics is a privately held, early-stage biotechnology company pioneering the field of Exoneural Biology – the neural regulation of cancer, immunity, and regeneration. Cygnal is developing drugs to manipulate Exoneural Biology for the treatment of cancer, immunological diseases, and regenerative processes. Cygnal Therapeutics was founded by Flagship Pioneering, in the VentureLabs innovation foundry, which has created over 50 groundbreaking companies that are developing novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability.

The Position

Cygnal is seeking a Scientist to help us advance the science of Exoneural Biology in immunology and to develop therapeutic hypotheses from target identification, pathway validation, therapeutic development and beyond. The candidate must be independent and goal oriented, and able to efficiently lead teams and complete multiple projects in parallel. The position will require creativity, resourcefulness, and adaptability. The candidate will be responsible for the direction and execution of projects, including novel assay development, in vitro proof-of concept, and in vivo translational studies, and aligning the scientific plan with corporate objectives. We are searching for enthusiastic, innovative, and highly motivated individuals who are comfortable working in a fastpaced entrepreneurial environment.

Responsibilities

- Design experimental plans for pathway validation and target identification, including assay development in vitro and in vivo, in collaboration with the scientific team

- Execute experiments, generate and analyze data, and communicate data to scientific team and executive management

- Lead and collaborate with other scientists and research associates to achieve company objectives

- Manage external research relationships with academic and commercial partners

Skills & Abilities

- Immunologist with a focus on myeloid lineage (dendritic cells, macrophages, etc)

- Research experience in inflammatory diseases, autoimmune diseases, and/or mucosal immunology

- Strong experimental skills, especially assay development (in vitro & in vivo models), cell and molecular immunology. Expertise in multi-color flow cytometry immune cell phenotyping, tissue isolation techniques and assays

- Motivated and curious, experienced working with highly technical projects and personnel.

- Highly adaptable and responsive to technical and business opportunities and needs – comfortable delivering against challenging commitments.

- Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.

- Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment.

Education & Experience

- PhD or equivalent in the biological sciences, bioengineering, or related field.

- 5+ years of relevant laboratory experience, in academic, pharmaceutical or biotechnology settings.

- Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial and technical setting.

Contact Information

To learn more about this exciting career opportunity please submit your resume and cover letter to Info@cygnaltx.com.